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Literature summary for 2.3.1.176 extracted from
- Sterol carrier protein-x gene and effects of sterol carrier protein-2 inhibitors on lipid uptake in Manduca sexta (2010), BMC Physiol., 10, 9.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | targeting insect SCP-2 may be a viable approach for the development of insecticides | Manduca sexta |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene MsSCP-x/SCP-2, from larval fat body and midgut, cDNA and amino acid sequence determination and analysis, sequence comparison | Manduca sexta |
| gene SCP-2, from larval fat body and midgut, cDNA and amino acid sequence determination and analysis, sequence comparison | Manduca sexta |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Manduca sexta | D8VD26 | sterol carrier protein 2/3-oxoacyl-CoA thiolase, SCP-x; sterol carrier protein-x/the sterol carrier protein-2, MsSCP-x/SCP-2, gene | - |
| Manduca sexta | D8VD27 | sterol carrier protein 2, SCP-2; sterol carrier protein-2, SCP-2, gene | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fat body | larval | Manduca sexta | - |
| midgut | - |
Manduca sexta | - |
| additional information | MsSCP-x and MsSCP-2, semi-quantitative RT-PCR expression analysis, overview | Manduca sexta | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | recombinant MsSCP-2 binds to NBD-cholesterol with high affinity, which is suppressed by sterol carrier protein-2 inhibitors | Manduca sexta | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MsSCP-x/SCP-2 protein | - |
Manduca sexta |
| SCP-2 | - |
Manduca sexta |
| SCP-x | - |
Manduca sexta |
| sterol carrier protein-2 | - |
Manduca sexta |
| sterol carrier protein-x | - |
Manduca sexta |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the MsSCP-x/SCP-2 protein has a high degree of homology in the SCP-2 domain to other insect SCP-2 | Manduca sexta |
| physiological function | MsSCP-2 may function as a lipid carrier protein in vivo, MsSCP-2 is involved in cholesterol uptake in vivo, overview | Manduca sexta |
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