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Literature summary for 2.3.1.17 extracted from

  • Zand, B.; Previs, R.A.; Zacharias, N.M.; Rupaimoole, R.; Mitamura, T.; Nagaraja, A.S.; Guindani, M.; Dalton, H.J.; Yang, L.; Baddour, J.; Achreja, A.; Hu, W.; Pecot, C.V.; Ivan, C.; Wu, S.Y.; McCullough, C.R.; Gharpure, K.M.; Shoshan, E.; Pradeep, S.; Mangala, L.S.; Rodriguez-Aguayo, C.; Wang, Y.; Nick, A.M.
    Role of increased N-acetylaspartate levels in cancer (2016), J. Natl. Cancer Inst., 108, djv426 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine patients with high levels of tumoral N-acetyl-L-aspartate and its biosynthetic enzyme, aspartate N-acetyltransferase (NAT8L), have worse overall survival than patients with low levels of N-acetyl-L-aspartate and NAT8L. The overall survival duration of patients with higher-than-median N-acetyl-L-aspartate levels (3.6 years) is lower than that of patients with lower-than-median N-acetyl-L-aspartate levels (5.1 years). High NAT8L gene expression in other cancers (melanoma, renal cell, breast, colon, and uterine cancers) is associated with worse overall survival. NAT8L silencing reduces cancer cell viability and proliferation. In orthotopic mouse models (ovarian cancer and melanoma), NAT8L silencing reduces tumor growth statistically significantly Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N9F0
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Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
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 Homo sapiens
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A-375SM cell
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 Homo sapiens
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HEY-A8 cell
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 Homo sapiens
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M14 melanoma cell
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 Homo sapiens
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SKOV-3 cell
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 Homo sapiens
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UACC-257 cell
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 Homo sapiens
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UACC-62 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
NAT8L
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 Homo sapiens