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Literature summary for 2.3.1.17 extracted from

  • Mutthamsetty, V.; Dahal, G.P.; Wang, Q.; Viola, R.E.
    Development of bisubstrate analog inhibitors of aspartate N-acetyltransferase, a critical brain enzyme (2020), Chem. Biol. Drug Des., 95, 48-57 .
    View publication on PubMed
Search for more literature for 2.3.1.17

Inhibitors

Inhibitors Comment Organism Structure
adenosine 3',5'-monophosphate truncated bisubstrate analog Homo sapiens
adenosine 5'-diphosphate truncated bisubstrate analog Homo sapiens
adenosine 5'-monophosphate truncated bisubstrate analog Homo sapiens
adenosine 5'-triphosphate truncated bisubstrate analog Homo sapiens
N-acetyl-(dimethyl)aspartyl-conjugated CoA coenzyme A coupled to methylated N-acetyl aspartate, bisubstrate inhibitor Homo sapiens
N-acetylaspartate truncated bisubstrate analog Homo sapiens
N-acetylaspartyl-conjugated CoA coenzyme A coupled to N-acetyl aspartate, bisubstrate inhibitor Homo sapiens
N-chloroacetylaspartate truncated bisubstrate analog Homo sapiens
N-propionyl-(dimethyl)aspartyl-conjugated CoA coenzyme A coupled to N-propionyl aspartate, bisubstrate inhibitor Homo sapiens
N-[((2-[(tert-butoxycarbonyl)amino]ethyl)sulfanyl)acetyl]-L-aspartic acid truncated bisubstrate analog Homo sapiens
sodium 2-[(tert-butoxycarbonyl)amino]-3-[(2-([(1S)-1,2-dicarboxyethyl]amino)-2-oxoethyl)sulfanyl]propanoate truncated bisubstrate analog Homo sapiens
sodium 3-[(2-([(1S)-1,2-dicarboxyethyl]amino)-2-oxoethyl)sulfanyl]-2-([(trifluoromethoxy)carbonyl]amino)propanoate truncated bisubstrate analog Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N9F0
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000048
-
 N-propionyl-(dimethyl)aspartyl-conjugated CoA pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000275
-
 N-acetylaspartyl-conjugated CoA pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.018
-
 N-acetyl-(dimethyl)aspartyl-conjugated CoA pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.2
-
 N-chloroacetylaspartate pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.87
-
 sodium 2-[(tert-butoxycarbonyl)amino]-3-[(2-([(1S)-1,2-dicarboxyethyl]amino)-2-oxoethyl)sulfanyl]propanoate pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.96
-
 adenosine 5'-triphosphate pH not specified in the publication, temperature not specified in the publication Homo sapiens
1.03
-
 sodium 3-[(2-([(1S)-1,2-dicarboxyethyl]amino)-2-oxoethyl)sulfanyl]-2-([(trifluoromethoxy)carbonyl]amino)propanoate pH not specified in the publication, temperature not specified in the publication Homo sapiens
1.1
-
 adenosine 5'-diphosphate pH not specified in the publication, temperature not specified in the publication Homo sapiens
1.6
-
 N-acetylaspartate pH not specified in the publication, temperature not specified in the publication Homo sapiens
2.1
-
 N-[((2-[(tert-butoxycarbonyl)amino]ethyl)sulfanyl)acetyl]-L-aspartic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens
2.3
-
 adenosine 3',5'-monophosphate pH not specified in the publication, temperature not specified in the publication Homo sapiens
4
-
 adenosine 5'-monophosphate pH not specified in the publication, temperature not specified in the publication Homo sapiens