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BRENDA support

Literature summary for 2.3.1.168 extracted from

  • Hull, J.; Usmari Moraes, M.; Brookes, E.; Love, S.; Conway, M.
    Distribution of the branched-chain alpha-ketoacid dehydrogenase complex E1alpha subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism (2018), Neurochem. Int., 112, 49-58 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P09622 cf. EC 1.8.1.4
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Synonyms

Synonyms Comment Organism
DLD
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Homo sapiens

General Information

General Information Comment Organism
physiological function branched-chain amino acids are metabolized within both the vasculature and neurons in the human brain. Glutamate dehydrogenase isozymes, branched-chain aminotransferase and the branched-chain alpha-ketoacid dehydrogenase proteins may operate in conjunction with astrocytic glutamate transporters and glutamine synthetase to regulate the availability of glutamate Homo sapiens