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Literature summary for 2.3.1.165 extracted from

  • Campuzano, I.D.G.; Shoolingin-Jordan, P.M.
    Incubation of 6-methylsalicylic acid synthase with alternative starter units in the absence of NADPH and the identification of the resulting triaceticacid lactones (1998), Biochem. Soc. Trans., 26, S284.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Penicillium griseofulvum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA + malonyl-CoA 5% of the rate of 6-methylsalicylic acid synthesis Penicillium griseofulvum 6-methyl triacetic acid lactone + CoA
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?
acetyl-CoA + malonyl-CoA
-
Penicillium griseofulvum triacetic lactone
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?
acetyl-CoA + malonyl-CoA + NADPH
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Penicillium griseofulvum 6-methylsalicylate + CoA + CO2 + NADP+
-
?
butyryl-CoA + malonyl-CoA 5% of the rate of 6-methylsalicylic acid synthesis Penicillium griseofulvum 6-propyl triacetic acid lactone + CoA
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?
crotonyl-CoA + malonyl-CoA 5% of the rate of 6-methylsalicylic acid synthesis Penicillium griseofulvum 6-(2-propene) triacetic acid lactone + CoA
-
?
heptanoyl-CoA + malonyl-CoA 5% of the rate of 6-methylsalicylic acid synthesis Penicillium griseofulvum 6-hexyl triacetic acid lactone + CoA
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?
hexanoyl-CoA + malonyl-CoA 5% of the rate of 6-methylsalicylic acid synthesis Penicillium griseofulvum 6-pentyl triacetic acid lactone + CoA
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?
propionyl-CoA + malonyl-CoA 5% of the rate of 6-methylsalicylic acid synthesis Penicillium griseofulvum 6-ethyl triacetic acid lactone + CoA
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?
valeryl-CoA + malonyl-CoA 5% of the rate of 6-methylsalicylic acid synthesis Penicillium griseofulvum 6-butyl triacetic acid lactone + CoA
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?