BRENDA - Enzyme Database
show all sequences of 2.3.1.157

Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series

Green, O.M.; McKenzie, A.R.; Shapiro, A.B.; Otterbein, L.; Ni, H.; Patten, A.; Stokes, S.; Albert, R.; Kawatkar, S.; Breed, J.; Bioorg. Med. Chem. Lett. 22, 1510-1519 (2012)

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
purified GlmU, hanging drop vapour diffusion method, 20 mg/ml protein in 25 mM Tris–HCl, pH 7.5, 50 mM NaCl, 2 mM TCEP, is mixed with 2 mM inhibitor ligand, and incubated on ice for 30 min and centrifuged, then mixed with reservoir solution containing of 18-23% w/v PEG 3350, 200 mM ammonium sulfate and 100 mM PCTP, pH 7.0-8.0, 2-5 days, 20°C, X-ray diffraction structure determination and analysis
Streptococcus pneumoniae
purified GlmU, hanging drop vapour diffusion method, mixing of 8 mg/ml enzyme in 50 mM Tris/HCl, pH 8.0, 150 mM NaCl, 2 mM EDTA, 2 mM TCEP, with 2 mM inhibitor ligand, and with reservoir solution containing 19–22% w/v PEG 3350 and either 100 mM PCTP, pH 5.0, 100-200 mM ammonium sulfate or 100 mM MMT, pH 6.0-7.0, and 400 mM ammonium sulfate, 20°C, 2-7 days, X-ray diffraction structure determination and analysis
Escherichia coli
Inhibitors
Inhibitors
Commentary
Organism
Structure
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
Escherichia coli
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
Haemophilus influenzae
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
Staphylococcus aureus
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
Streptococcus pneumoniae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
Escherichia coli
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
Haemophilus influenzae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
Staphylococcus aureus
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
Streptococcus pneumoniae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
Escherichia coli
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
Haemophilus influenzae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
Staphylococcus aureus
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
Streptococcus pneumoniae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
Escherichia coli
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
Haemophilus influenzae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
Staphylococcus aureus
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
Streptococcus pneumoniae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
Escherichia coli
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
Haemophilus influenzae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
Staphylococcus aureus
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
Streptococcus pneumoniae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
Escherichia coli
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
Haemophilus influenzae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
Staphylococcus aureus
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
Streptococcus pneumoniae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
Escherichia coli
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
Haemophilus influenzae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
Staphylococcus aureus
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
Streptococcus pneumoniae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
Escherichia coli
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
Haemophilus influenzae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
Staphylococcus aureus
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
Streptococcus pneumoniae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Escherichia coli
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Haemophilus influenzae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Staphylococcus aureus
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Streptococcus pneumoniae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Escherichia coli
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Haemophilus influenzae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Staphylococcus aureus
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Streptococcus pneumoniae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
Escherichia coli
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
Haemophilus influenzae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
Staphylococcus aureus
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
Streptococcus pneumoniae
additional information
high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series
Escherichia coli
additional information
high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series
Haemophilus influenzae
additional information
high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series
Staphylococcus aureus
additional information
high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series
Streptococcus pneumoniae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
Escherichia coli
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
Haemophilus influenzae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
Staphylococcus aureus
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
Escherichia coli
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
Haemophilus influenzae
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
Staphylococcus aureus
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
Streptococcus pneumoniae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
Escherichia coli
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
Haemophilus influenzae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
Staphylococcus aureus
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
Streptococcus pneumoniae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + alpha-D-glucosamine 1-phosphate
Staphylococcus aureus
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
Haemophilus influenzae
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
Escherichia coli
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
Streptococcus pneumoniae
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Haemophilus influenzae
-
-
-
Staphylococcus aureus
-
-
-
Streptococcus pneumoniae
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
719064
Staphylococcus aureus
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
719064
Haemophilus influenzae
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
719064
Escherichia coli
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
719064
Streptococcus pneumoniae
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
Subunits
Subunits
Commentary
Organism
heterotrimer
-
Escherichia coli
heterotrimer
-
Haemophilus influenzae
heterotrimer
-
Staphylococcus aureus
heterotrimer
-
Streptococcus pneumoniae
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
22
-
assay at romm temperature
Escherichia coli
22
-
assay at romm temperature
Haemophilus influenzae
22
-
assay at romm temperature
Staphylococcus aureus
22
-
assay at romm temperature
Streptococcus pneumoniae
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.3
7.4
assay at
Escherichia coli
7.3
7.4
assay at
Haemophilus influenzae
7.3
7.4
assay at
Staphylococcus aureus
7.3
7.4
assay at
Streptococcus pneumoniae
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00009
-
pH 7.35, 22°C
Escherichia coli
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.0001
-
pH 7.35, 22°C
Escherichia coli
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.0002
-
pH 7.35, 22°C
Escherichia coli
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.0002
-
pH 7.35, 22°C
Haemophilus influenzae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.00025
-
pH 7.35, 22°C
Escherichia coli
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0003
-
pH 7.35, 22°C
Haemophilus influenzae
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.0004
-
pH 7.35, 22°C
Escherichia coli
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.0005
-
pH 7.35, 22°C
Escherichia coli
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.0005
-
pH 7.35, 22°C
Escherichia coli
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.0005
-
pH 7.35, 22°C
Haemophilus influenzae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0005
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0005
-
pH 7.35, 22°C
Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.0005
-
pH 7.35, 22°C
Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.0006
-
pH 7.35, 22°C
Haemophilus influenzae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.0009
-
pH 7.35, 22°C
Escherichia coli
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.001
-
pH 7.35, 22°C
Haemophilus influenzae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.001
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.001
-
pH 7.35, 22°C
Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.0015
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.002
-
pH 7.35, 22°C
Streptococcus pneumoniae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.002
-
pH 7.35, 22°C
Escherichia coli
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.002
-
pH 7.35, 22°C
Haemophilus influenzae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.002
-
pH 7.35, 22°C
Haemophilus influenzae
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.002
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.002
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.002
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.003
-
pH 7.35, 22°C
Escherichia coli
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.003
-
pH 7.35, 22°C
Haemophilus influenzae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.003
-
pH 7.35, 22°C
Escherichia coli
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.003
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.003
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.004
-
pH 7.35, 22°C
Escherichia coli
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.005
-
pH 7.35, 22°C
Haemophilus influenzae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.005
-
pH 7.35, 22°C
Haemophilus influenzae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.005
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.005
-
pH 7.35, 22°C
Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.005
-
pH 7.35, 22°C
Escherichia coli
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.006
-
pH 7.35, 22°C
Haemophilus influenzae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.006
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.006
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.008
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.01
-
pH 7.35, 22°C
Streptococcus pneumoniae
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.01
-
pH 7.35, 22°C
Staphylococcus aureus
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.01
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.01
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.012
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.015
-
pH 7.35, 22°C
Streptococcus pneumoniae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.015
-
pH 7.35, 22°C
Escherichia coli
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.015
-
pH 7.35, 22°C
Escherichia coli
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.015
-
pH 7.35, 22°C
Escherichia coli
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.016
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.017
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.02
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.02
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.02
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.02
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.021
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.025
-
pH 7.35, 22°C
Escherichia coli
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.03
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.03
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.04
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.04
-
pH 7.35, 22°C
Escherichia coli
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.047
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.05
-
pH 7.35, 22°C
Staphylococcus aureus
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.055
-
pH 7.35, 22°C
Haemophilus influenzae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.055
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.06
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.07
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.07
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.08
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.08
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.08
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.09
-
pH 7.35, 22°C
Streptococcus pneumoniae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.1
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.11
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.12
-
pH 7.35, 22°C
Haemophilus influenzae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.13
-
pH 7.35, 22°C
Escherichia coli
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.2
-
above, pH 7.35, 22°C
Escherichia coli
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Escherichia coli
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Escherichia coli
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Escherichia coli
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.54
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
Crystallization (Commentary) (protein specific)
Crystallization
Organism
purified GlmU, hanging drop vapour diffusion method, 20 mg/ml protein in 25 mM Tris–HCl, pH 7.5, 50 mM NaCl, 2 mM TCEP, is mixed with 2 mM inhibitor ligand, and incubated on ice for 30 min and centrifuged, then mixed with reservoir solution containing of 18-23% w/v PEG 3350, 200 mM ammonium sulfate and 100 mM PCTP, pH 7.0-8.0, 2-5 days, 20°C, X-ray diffraction structure determination and analysis
Streptococcus pneumoniae
purified GlmU, hanging drop vapour diffusion method, mixing of 8 mg/ml enzyme in 50 mM Tris/HCl, pH 8.0, 150 mM NaCl, 2 mM EDTA, 2 mM TCEP, with 2 mM inhibitor ligand, and with reservoir solution containing 19–22% w/v PEG 3350 and either 100 mM PCTP, pH 5.0, 100-200 mM ammonium sulfate or 100 mM MMT, pH 6.0-7.0, and 400 mM ammonium sulfate, 20°C, 2-7 days, X-ray diffraction structure determination and analysis
Escherichia coli
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00009
-
pH 7.35, 22°C
Escherichia coli
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.0001
-
pH 7.35, 22°C
Escherichia coli
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.0002
-
pH 7.35, 22°C
Escherichia coli
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.0002
-
pH 7.35, 22°C
Haemophilus influenzae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.00025
-
pH 7.35, 22°C
Escherichia coli
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0003
-
pH 7.35, 22°C
Haemophilus influenzae
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.0004
-
pH 7.35, 22°C
Escherichia coli
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.0005
-
pH 7.35, 22°C
Escherichia coli
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.0005
-
pH 7.35, 22°C
Escherichia coli
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.0005
-
pH 7.35, 22°C
Haemophilus influenzae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0005
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0005
-
pH 7.35, 22°C
Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.0005
-
pH 7.35, 22°C
Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.0006
-
pH 7.35, 22°C
Haemophilus influenzae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.0009
-
pH 7.35, 22°C
Escherichia coli
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.001
-
pH 7.35, 22°C
Haemophilus influenzae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.001
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.001
-
pH 7.35, 22°C
Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.0015
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.002
-
pH 7.35, 22°C
Streptococcus pneumoniae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.002
-
pH 7.35, 22°C
Escherichia coli
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.002
-
pH 7.35, 22°C
Haemophilus influenzae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.002
-
pH 7.35, 22°C
Haemophilus influenzae
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.002
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.002
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.002
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.003
-
pH 7.35, 22°C
Escherichia coli
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.003
-
pH 7.35, 22°C
Haemophilus influenzae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.003
-
pH 7.35, 22°C
Escherichia coli
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.003
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.003
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.004
-
pH 7.35, 22°C
Escherichia coli
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.005
-
pH 7.35, 22°C
Haemophilus influenzae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.005
-
pH 7.35, 22°C
Haemophilus influenzae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.005
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.005
-
pH 7.35, 22°C
Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.005
-
pH 7.35, 22°C
Escherichia coli
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.006
-
pH 7.35, 22°C
Haemophilus influenzae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.006
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.006
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.008
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.01
-
pH 7.35, 22°C
Streptococcus pneumoniae
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.01
-
pH 7.35, 22°C
Staphylococcus aureus
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.01
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.01
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.012
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.015
-
pH 7.35, 22°C
Streptococcus pneumoniae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.015
-
pH 7.35, 22°C
Escherichia coli
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.015
-
pH 7.35, 22°C
Escherichia coli
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.015
-
pH 7.35, 22°C
Escherichia coli
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.016
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.017
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.02
-
pH 7.35, 22°C
Streptococcus pneumoniae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.02
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.02
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.02
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.021
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.025
-
pH 7.35, 22°C
Escherichia coli
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.03
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.03
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.04
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.04
-
pH 7.35, 22°C
Escherichia coli
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.047
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.05
-
pH 7.35, 22°C
Staphylococcus aureus
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.055
-
pH 7.35, 22°C
Haemophilus influenzae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.055
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.06
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.07
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.07
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.08
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.08
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.08
-
pH 7.35, 22°C
Haemophilus influenzae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.09
-
pH 7.35, 22°C
Streptococcus pneumoniae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.1
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.11
-
pH 7.35, 22°C
Streptococcus pneumoniae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.12
-
pH 7.35, 22°C
Haemophilus influenzae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.13
-
pH 7.35, 22°C
Escherichia coli
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.2
-
above, pH 7.35, 22°C
Escherichia coli
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2
-
pH 7.35, 22°C
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Escherichia coli
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Escherichia coli
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Escherichia coli
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Haemophilus influenzae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Staphylococcus aureus
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2
-
above, pH 7.35, 22°C
Streptococcus pneumoniae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.54
-
pH 7.35, 22°C
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
Escherichia coli
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
Haemophilus influenzae
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
Staphylococcus aureus
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
Streptococcus pneumoniae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
Escherichia coli
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
Haemophilus influenzae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
Staphylococcus aureus
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
Streptococcus pneumoniae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
Escherichia coli
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
Haemophilus influenzae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
Staphylococcus aureus
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
Streptococcus pneumoniae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
Escherichia coli
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
Haemophilus influenzae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
Staphylococcus aureus
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
Streptococcus pneumoniae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
Escherichia coli
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
Haemophilus influenzae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
Staphylococcus aureus
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
Streptococcus pneumoniae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
Escherichia coli
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
Haemophilus influenzae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
Staphylococcus aureus
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
Streptococcus pneumoniae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
Escherichia coli
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
Haemophilus influenzae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
Staphylococcus aureus
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
Streptococcus pneumoniae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
Escherichia coli
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
Haemophilus influenzae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
Staphylococcus aureus
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
Streptococcus pneumoniae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Escherichia coli
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Haemophilus influenzae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Staphylococcus aureus
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Streptococcus pneumoniae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Escherichia coli
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Haemophilus influenzae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Staphylococcus aureus
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
Streptococcus pneumoniae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
Escherichia coli
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
Haemophilus influenzae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
Staphylococcus aureus
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
Streptococcus pneumoniae
additional information
high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series
Escherichia coli
additional information
high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series
Haemophilus influenzae
additional information
high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series
Staphylococcus aureus
additional information
high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series
Streptococcus pneumoniae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
Escherichia coli
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
Haemophilus influenzae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
Staphylococcus aureus
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
Escherichia coli
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
Haemophilus influenzae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
Staphylococcus aureus
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
Streptococcus pneumoniae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Escherichia coli
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Haemophilus influenzae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Staphylococcus aureus
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
Streptococcus pneumoniae
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
Escherichia coli
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
Haemophilus influenzae
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
Staphylococcus aureus
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
Streptococcus pneumoniae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
Escherichia coli
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
Haemophilus influenzae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
Staphylococcus aureus
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
Streptococcus pneumoniae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + alpha-D-glucosamine 1-phosphate
Staphylococcus aureus
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
Haemophilus influenzae
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
Escherichia coli
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
Streptococcus pneumoniae
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
719064
Staphylococcus aureus
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
719064
Haemophilus influenzae
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
719064
Escherichia coli
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
719064
Streptococcus pneumoniae
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
heterotrimer
-
Escherichia coli
heterotrimer
-
Haemophilus influenzae
heterotrimer
-
Staphylococcus aureus
heterotrimer
-
Streptococcus pneumoniae
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
22
-
assay at romm temperature
Escherichia coli
22
-
assay at romm temperature
Haemophilus influenzae
22
-
assay at romm temperature
Staphylococcus aureus
22
-
assay at romm temperature
Streptococcus pneumoniae
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.3
7.4
assay at
Escherichia coli
7.3
7.4
assay at
Haemophilus influenzae
7.3
7.4
assay at
Staphylococcus aureus
7.3
7.4
assay at
Streptococcus pneumoniae
General Information
General Information
Commentary
Organism
physiological function
the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate
Escherichia coli
physiological function
the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate
Haemophilus influenzae
physiological function
the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate
Staphylococcus aureus
physiological function
the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate
Streptococcus pneumoniae
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate
Escherichia coli
physiological function
the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate
Haemophilus influenzae
physiological function
the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate
Staphylococcus aureus
physiological function
the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate
Streptococcus pneumoniae
Other publictions for EC 2.3.1.157
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746844
Honda
Improvement of ST0452 N-acety ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993
Appl. Environ. Microbiol.
84
e002213-18
2018
-
-
1
1
2
-
-
-
-
-
-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
736517
Sharma
Escherichia coli N-acetylgluco ...
Escherichia coli, Escherichia coli ATCC 25922
J. Biomol. Screen.
21
342-353
2016
-
-
1
-
-
-
3
-
-
1
-
2
-
10
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
4
-
2
-
-
1
1
-
-
-
2
4
4
-
-
1
-
2
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
737096
Dziadek
Mycobacterium tuberculosis Ats ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618, Mycobacterium tuberculosis H37Rv
PLoS ONE
11
e0148030
2016
-
1
1
-
1
-
-
-
-
-
-
3
-
15
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
729696
Zhang
Characterization of the amino ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7, Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7
Extremophiles
19
417-427
2015
-
1
1
-
7
-
1
9
-
1
-
6
-
8
-
-
1
-
-
-
12
-
9
2
1
-
1
6
1
-
-
1
-
-
-
-
1
1
1
-
7
-
-
1
-
9
-
1
-
6
-
-
-
1
-
-
12
-
9
2
1
-
1
6
1
-
-
-
-
2
2
-
6
6
735518
Sharma
Identification and characteriz ...
Escherichia coli, Escherichia coli ATCC 25922, Haemophilus influenzae, Haemophilus influenzae ATCC 51907
Appl. Microbiol. Biotechnol.
100
3071-3085
2015
-
-
1
-
-
-
15
-
-
-
-
8
-
12
-
-
1
-
-
-
-
-
10
-
2
-
-
-
2
-
-
2
2
-
11
-
-
1
2
-
-
-
12
17
2
-
-
-
-
8
-
-
-
1
-
-
-
-
10
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
735569
Patin
Purification and biochemical c ...
Yersinia pestis, Yersinia pestis YPIII, Yersinia pseudotuberculosis, Yersinia pseudotuberculosis YPIII
Arch. Microbiol.
197
371-378
2015
1
-
2
-
1
-
2
4
-
2
-
2
-
6
-
-
1
-
-
-
-
-
4
2
1
-
-
4
1
-
-
1
-
-
-
1
-
2
1
-
1
-
-
2
-
4
-
2
-
2
-
-
-
1
-
-
-
-
4
2
1
-
-
4
1
-
-
-
-
2
2
-
-
-
737150
Soni
Depletion of M. tuberculosis G ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618, Mycobacterium tuberculosis H37Rv
PLoS Pathog.
11
e1005235
2015
-
1
1
1
-
-
2
-
-
-
-
6
-
12
-
-
-
-
-
-
-
-
6
-
1
-
-
-
1
-
-
1
-
-
1
-
1
1
1
1
-
-
1
2
-
-
-
-
-
6
-
-
-
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
737291
Rani
High-throughput screen identif ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Tuberculosis
95
664-677
2015
-
-
1
-
-
-
6
3
-
1
-
4
-
11
-
-
1
-
-
-
-
-
5
-
1
-
-
-
1
-
-
1
5
-
10
-
-
1
1
-
-
-
10
8
5
5
-
1
-
4
-
-
-
1
-
-
-
-
5
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
735396
Vithani
GlmU (N-acetylglucosamine-1-ph ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Acta Crystallogr. Sect. F
70
703-708
2014
-
-
1
1
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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