Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P97564 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | upon stable overexpression of isoform Gpat1, lysophosphatidic acid levels in CHO-GPAT1 cells are 6fold higher than in wild-type CHO cells, and the mRNA abundance of CD36, a target of peroxisome proliferator activated receptor PPARgamma, is 2fold higher. PPARgamma activity is higher in the cells that overexpress isoform GPAT1. PPARgamma activity is further enhanced in CHO-GPAT1 cells treated with the PPARgamma ligand troglitazone. Extracellular LPA, phosphatidic acid or a membrane-permeable diacylglycerol have no effect | Rattus norvegicus |