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Literature summary for 2.3.1.149 extracted from

  • Tsoukatos, D.C.; Brocheriou, I.; Moussis, V.; Panopoulou, C.P.; Christofidou, E.D.; Koussissis, S.; Sismanidis, S.; Ninio, E.; Siminelakis, S.
    Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery (2008), J. Lipid Res., 49, 2240-2249.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.149

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta immunohistochemistry shows PAF-AH expression in the intima and in the media of the aorta Homo sapiens
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artery detected by immunohistochemistry in the media of mammary arteries Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000008
-
 transacetylase activity of mammary artery Homo sapiens
0.0000033
-
 transacetylase activity in aorta Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + lyso-phosphatidylcholine
-
 Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
PAF-AH enzyme inactivates PAF bioactivity and possesses both acetylhydrolase and transacetylase activities Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function lyso- platelet-activating factor accumulation and an increase in platelet-activating factor bioactivity is observed in the aorta of some patients. In atherogenic aortas, an imbalance between PAF-AH and transacetylase activity, as well as lyso-platelet-activating factor accumulation, may lead to unregulated platelet-activating factor formation and to progression of atherosclerosis Homo sapiens