Reference to 2.3.1.148; Id = 16278 - BRENDA Enzyme Database

Zn2+

strong

Rattus norvegicus

0.0015

-

1-hexadecyl-2-lyso-glycerophosphocholine

-

Oryctolagus cuniculus

0.0038

-

1-acyl-2-lyso-glycerophosphocholine

-

Oryctolagus cuniculus

0.017

-

1-palmitoyl-2-lyso-glycerophosphocholine

-

Rattus norvegicus

0.076

-

lyso-phosphatidylserine

-

Homo sapiens

microsome

-

Rattus norvegicus

-

microsome

-

Oryctolagus cuniculus

-

microsome

-

Canis lupus familiaris

-

Canis lupus familiaris

-

Homo sapiens

-

Mus musculus

-

Oryctolagus cuniculus

-

Rattus norvegicus

-

alveolar macrophage

-

Oryctolagus cuniculus

-

heart

-

Canis lupus familiaris

-

liver

-

Rattus norvegicus

-

liver

-

Oryctolagus cuniculus

-

lung

-

Rattus norvegicus

-

lymphocyte

-

Mus musculus

-

macrophage

-

Mus musculus

-

platelet

-

Homo sapiens

-

platelet

-

Rattus norvegicus

-

1-Acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

transfer of arachidonate occurs through a bidirectional movement

16278

Mus musculus

1-Acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine

-

?

1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + lyso-phosphatidylcholine

-

16278

Mus musculus

1-acyl-2-lyso-sn-glycero-3-phosphoinositol + ?

-

?

1-Acyl-2-arachidonoyl-sn-glycero-3-phosphophoinositol + lyso-phosphatidylethanolamine

unidirectional transfer process of arachidonate

16278

Mus musculus

1-Acyl-2-lyso-sn-glycero-3-phosphoinositol + arachidonoylphosphatidylethanolamine

-

?

1-acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine

-

16278

Oryctolagus cuniculus

1-acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

-

r

1-Hexadecyl-2-lyso-glycerophosphocholine + phospholipid

-

16278

Oryctolagus cuniculus

?

-

?

1-palmitoyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine

-

16278

Rattus norvegicus

1-palmitoyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

-

r

lyso-Pasmenylethanolamine + phospholipid

-

16278

Homo sapiens

?

-

?

lyso-Phosphatidylethanolamine + phospholipid

-

16278

Homo sapiens

Phosphatidylethanolamine + lyso-phospholipid

-

?

lyso-Phosphatidylinositol + phospholipid

-

16278

Homo sapiens

Phosphatidylinositol + lyso-phospholipid

-

?

lyso-Phosphatidylserine + phospholipid

-

16278

Homo sapiens

Phosphatidylserine + lyso-phospholipid

-

?

additional information

arachidonate and linoleate at the sn-2 position of phosphatidylcholine can be transferred to lyso-phosphatidylethanolamine. The transfer of 16:0, 18:0, and 18:1 acyl moieties at the sn-2-position of phosphatidylcholine is negligible

16278

Rattus norvegicus

?

-

?

additional information

more efficient transfer of arachidonate from phosphatidylcholine to the ethanolamine-containing phospholipids than from phosphatidylinositol

16278

Homo sapiens

?

-

?

Phosphatidylcholine + lyso-phosphatidylethanolamine

-

16278

Mus musculus

lyso-Phosphatidylcholine + phosphatidylethanolamine

-

?

4.5

-

bimodal pH-optimum, at pH 4.5 and at pH 7.5. The activity is 4-5times higher at pH 4.5 than at pH 7.5

Canis lupus familiaris

7.5

-

Rattus norvegicus

7.5

-

bimodal pH-optimum, at pH 7.5 and at pH 4.5

Canis lupus familiaris

CoA

-

Canis lupus familiaris

CoA

required

Mus musculus

CoA

required

Homo sapiens

CoA

required

Rattus norvegicus

CoA

required

Oryctolagus cuniculus

CoA

Km: 0.0015 mM, lung enzyme, with lyso-phosphatidylethanolamine as substrate

Rattus norvegicus

CoA

Km: 0.014 mM, liver enzyme, with 2-lyso-sn-phosphatidylinositol as substrate

Rattus norvegicus

CoA

Km: 0.0014 mM

Homo sapiens

CoA

Km: 0.0014 mM

Oryctolagus cuniculus

CoA

-

Canis lupus familiaris

CoA

required

Mus musculus

CoA

required

Homo sapiens

CoA

required

Rattus norvegicus

CoA

required

Oryctolagus cuniculus

CoA

Km: 0.0015 mM, lung enzyme, with lyso-phosphatidylethanolamine as substrate

Rattus norvegicus

CoA

Km: 0.014 mM, liver enzyme, with 2-lyso-sn-phosphatidylinositol as substrate

Rattus norvegicus

CoA

Km: 0.0014 mM

Homo sapiens

CoA

Km: 0.0014 mM

Oryctolagus cuniculus

Zn2+

strong

Rattus norvegicus

0.0015

-

1-hexadecyl-2-lyso-glycerophosphocholine

-

Oryctolagus cuniculus

0.0038

-

1-acyl-2-lyso-glycerophosphocholine

-

Oryctolagus cuniculus

0.017

-

1-palmitoyl-2-lyso-glycerophosphocholine

-

Rattus norvegicus

0.076

-

lyso-phosphatidylserine

-

Homo sapiens

microsome

-

Rattus norvegicus

-

microsome

-

Oryctolagus cuniculus

-

microsome

-

Canis lupus familiaris

-

alveolar macrophage

-

Oryctolagus cuniculus

-

heart

-

Canis lupus familiaris

-

liver

-

Rattus norvegicus

-

liver

-

Oryctolagus cuniculus

-

lung

-

Rattus norvegicus

-

lymphocyte

-

Mus musculus

-

macrophage

-

Mus musculus

-

platelet

-

Homo sapiens

-

platelet

-

Rattus norvegicus

-

1-Acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

transfer of arachidonate occurs through a bidirectional movement

16278

Mus musculus

1-Acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine

-

?

1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + lyso-phosphatidylcholine

-

16278

Mus musculus

1-acyl-2-lyso-sn-glycero-3-phosphoinositol + ?

-

?

1-Acyl-2-arachidonoyl-sn-glycero-3-phosphophoinositol + lyso-phosphatidylethanolamine

unidirectional transfer process of arachidonate

16278

Mus musculus

1-Acyl-2-lyso-sn-glycero-3-phosphoinositol + arachidonoylphosphatidylethanolamine

-

?

1-acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine

-

16278

Oryctolagus cuniculus

1-acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

-

r

1-Hexadecyl-2-lyso-glycerophosphocholine + phospholipid

-

16278

Oryctolagus cuniculus

?

-

?

1-palmitoyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine

-

16278

Rattus norvegicus

1-palmitoyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

-

r

lyso-Pasmenylethanolamine + phospholipid

-

16278

Homo sapiens

?

-

?

lyso-Phosphatidylethanolamine + phospholipid

-

16278

Homo sapiens

Phosphatidylethanolamine + lyso-phospholipid

-

?

lyso-Phosphatidylinositol + phospholipid

-

16278

Homo sapiens

Phosphatidylinositol + lyso-phospholipid

-

?

lyso-Phosphatidylserine + phospholipid

-

16278

Homo sapiens

Phosphatidylserine + lyso-phospholipid

-

?

additional information

arachidonate and linoleate at the sn-2 position of phosphatidylcholine can be transferred to lyso-phosphatidylethanolamine. The transfer of 16:0, 18:0, and 18:1 acyl moieties at the sn-2-position of phosphatidylcholine is negligible

16278

Rattus norvegicus

?

-

?

additional information

more efficient transfer of arachidonate from phosphatidylcholine to the ethanolamine-containing phospholipids than from phosphatidylinositol

16278

Homo sapiens

?

-

?

Phosphatidylcholine + lyso-phosphatidylethanolamine

-

16278

Mus musculus

lyso-Phosphatidylcholine + phosphatidylethanolamine

-

?

4.5

-

bimodal pH-optimum, at pH 4.5 and at pH 7.5. The activity is 4-5times higher at pH 4.5 than at pH 7.5

Canis lupus familiaris

7.5

-

Rattus norvegicus

7.5

-

bimodal pH-optimum, at pH 7.5 and at pH 4.5

Canis lupus familiaris

16278

Snyder

The role of transacylases in t ...

Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus

Prog. Lipid Res.

31

65-86

1992

-

1

4

3

-

5

-

9

-

13

-

3

-

9

-

9

-

1

-

4

3

-

9

-

13

-

3

-

16275

Robinson

Acylation of lysophospholipids ...

Oryctolagus cuniculus

J. Biol. Chem.

260

7889-7895

1985

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

16276

Irvine

Transfer of arachidonic acid b ...

Rattus norvegicus

Biochem. Biophys. Res. Commun.

91

1399-1405

1979

-

1

-

1

-

1

-

2

-

2

-

2

-

1

-

1

-

2

-

The role of transacylases in the metabolism of arachidonate and platelet activating factor

Data extracted from this reference: