Application | Comment | Organism |
---|---|---|
medicine | disruption of arachidonic acid remodeling in a manner that increases intracellular arachidonic acid level involving inhibition of the enzyme may represent a novel therapeutic strategy to reduce cancer cell proliferation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of the enzyme attenuates the proliferation of breast cancer cell lines, intracellular level and distribution of free or triglyceride arachidonic acid, or an oxidized metabolite thereof, and blockage of remodeling are responsible for the effect, overview | Homo sapiens | |
SB-98625 | i.e. SKF 98625 or diethyl-7-(3,4,5-triphenyl-2-oxo-2,3-dihydroimidazol-1-yl)hepatine phosphate, inhibitor blocks the replication of MDA-MB-231 cells in early to mid G1 phase, induces early rounding and occasional blebbing of the cells, but not late apoptosis, blistering, and lysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | estrogen receptor-positive breast cancer cell | Homo sapiens | - |
MDA-MB-231 cell | estrogen receptor-negative breast cancer cell | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CoA-IT | - |
Homo sapiens |
Coenzyme A-independent transacylase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens |