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Literature summary for 2.3.1.147 extracted from

  • Trimboli, A.J.; Waite, B.M.; Atsumi, G.I.; Fonteh, A.N.; Namen, A.M.; Clay, C.E.; Kute, T.E.; High, K.P.; Willingham, M.C.; Chilton, F.H.
    Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells (1999), Cancer Res., 59, 6171-6177.
    View publication on PubMed

Application

Application Comment Organism
medicine disruption of arachidonic acid remodeling in a manner that increases intracellular arachidonic acid level involving inhibition of the enzyme may represent a novel therapeutic strategy to reduce cancer cell proliferation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of the enzyme attenuates the proliferation of breast cancer cell lines, intracellular level and distribution of free or triglyceride arachidonic acid, or an oxidized metabolite thereof, and blockage of remodeling are responsible for the effect, overview Homo sapiens
SB-98625 i.e. SKF 98625 or diethyl-7-(3,4,5-triphenyl-2-oxo-2,3-dihydroimidazol-1-yl)hepatine phosphate, inhibitor blocks the replication of MDA-MB-231 cells in early to mid G1 phase, induces early rounding and occasional blebbing of the cells, but not late apoptosis, blistering, and lysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell estrogen receptor-positive breast cancer cell Homo sapiens
-
MDA-MB-231 cell estrogen receptor-negative breast cancer cell Homo sapiens
-

Synonyms

Synonyms Comment Organism
CoA-IT
-
Homo sapiens
Coenzyme A-independent transacylase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Homo sapiens