Any feedback?
Literature summary for 2.3.1.137 extracted from
- Properties of the medium chain/long chain carnitine acyltransferase purified from rat liver microsomes (1993), J. Biol. Chem., 268, 4519-4524.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aminocarnitine | - |
Rattus norvegicus |  |
| D-carnitine | - |
Rattus norvegicus | |
| etomoxiryl-CoA | - |
Rattus norvegicus | |
| malonyl-CoA | microsomal COT, no inhibition of the mitochondrial enzyme | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| microsome | - |
Rattus norvegicus | - |
- |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | 55000 | SDS-PAGE | Rattus norvegicus |
| 53000 | - |
Western blot, polyclonal antibody reaction | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Rattus norvegicus | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-L-carnitine + CoA | Rattus norvegicus | - |
acyl-CoA + L-carnitine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-methylglutaryl-CoA + L-carnitine | little capacity to use this substrate | Rattus norvegicus | 3-methylglutaryl-L-carnitine + CoA | - |
r | |
| 3-methylglutaryl-L-carnitine + CoA | - |
Rattus norvegicus | 3-methylglutaryl-CoA + L-carnitine | - |
r | |
| acyl-CoA + L-carnitine | - |
Rattus norvegicus | acyl-L-carnitine + CoA | - |
r | |
| acyl-L-carnitine + CoA | - |
Rattus norvegicus | acyl-CoA + L-carnitine | - |
r | |
| beta-hydroxy-beta-methylglutaryl-L-carnitine + CoA | - |
Rattus norvegicus | beta-hydroxy-beta-methylglutaryl-CoA + L-carnitine | - |
r | |
| decanoyl-CoA + L-carnitine | - |
Rattus norvegicus | L-decanoyl-L-carnitine + CoA | - |
r | |
| decanoyl-L-carnitine + CoA | - |
Rattus norvegicus | decanoyl-CoA + L-carnitine | - |
r | |
| pivaloyl-CoA + L-carnitine | little capacity to use this substrate | Rattus norvegicus | L-pivaloyl-L-carnitine + CoA | - |
r | |
| pivaloyl-L-carnitine + CoA | - |
Rattus norvegicus | pivaloyl-CoA + L-carnitine | - |
r | |
| valproyl-CoA + L-carnitine | little capacity to use this substrate | Rattus norvegicus | L-valproyl-L-carnitine + CoA | - |
r | |
| valproyl-L-carnitine + CoA | - |
Rattus norvegicus | valproyl-CoA + L-carnitine | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COT | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
