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BRENDA support

Literature summary for 2.3.1.135 extracted from

  • Uppal, S.; Liu, T.; Poliakov, E.; Gentleman, S.; Redmond, T.M.
    The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function (2019), Sci. Rep., 9, 5218 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C161S hypomorphic mutant Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus Q9BGL2
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-

Source Tissue

Source Tissue Comment Organism Textmining
eye
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Bos taurus
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General Information

General Information Comment Organism
physiological function retinoid isomerohydrolase RPE65 palmitoylation level is highly regulated by lecithin:retinol acyltransferase (LRAT) enzyme. In the presence of LRAT substrate all-trans retinol, there is a significant decrease in the level of palmitoylation of RPE65 Bos taurus