Literature summary for 2.3.1.135 extracted from

Kida, Y.; Xia, Z.; Zheng, S.; Mordwinkin, N.M.; Louie, S.G.; Zheng, S.G.; Feng, M.; Shi, H.; Duan, Z.; Han, Y.P.
Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase (2011), PLoS ONE, 6, e26644.

Search for more literature for 2.3.1.135

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatic stellate cell	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
lecithin retinol acyltransferase	-	Rattus norvegicus
LRAT	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	interleukin-1 can potently downregulate mRNA and protein levels of LRAT and act as injury signal resulting in mobilization of retinyl esters in primary rat hepatic stellate cells. Secreted factors from Kupffer cells are able to suppress LRAT expression in hepatic stellate cells, which is neutralized by interleukin-1 receptor antagonist. The regulation is likely at transcriptional level. Interleukin-1 fails to downregulate recombinant LRAT protein expressed in the cells by adenovirus, while transcription of endogenous LRAT is promptly decreased. Interleukin-1 is a key mediator to down-regulate LRAT in liver injury	down

General Information

General Information	Comment	Organism
physiological function	downregulation of LRAT expression in rat hepatic stellate cells is required for mobilization of retinyl ester in liver injury for tissue repair and wound healing, interleukin-1 is a potent suppressor of LRAT with a hierarchy role in the transcriptional regulation, interleukin-1 does not regulate the stability of LRAT protein. Interleukin-1 is a key mediator to down-regulate LRAT in liver injury	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)