Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fenretinide | used clinically to presumably lower blood retinol-binding protein levels and thus decrease circulating retinol, targets the functional coupling of STRA6 and LRAT to increase cellular vitamin A uptake in peripheral tissues | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | Mus musculus | - |
2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | Mus musculus C57/BL6J / 129 Sv | - |
2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene Lrat | - |
Mus musculus C57/BL6J / 129 Sv | - |
gene Lrat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | - |
Mus musculus | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | refolded holo-hRBP from human serum | Mus musculus | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | - |
Mus musculus C57/BL6J / 129 Sv | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | refolded holo-hRBP from human serum | Mus musculus C57/BL6J / 129 Sv | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lecithin:retinol acyltransferase | - |
Mus musculus |
LRAT | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | vitamin A uptake from recombinant holo-retinol-binding protein exhibited by wild-type mice is impaired in Lrat-deficient mice. Lrat-/- mice show elevated cellular vitamin A-binding protein 1, CRBP1, protein in the liver, lung, and adipose tissue as compared with wild type control animals | Mus musculus |
physiological function | lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein, which depends on functional coupling of STRA6 with intracellular lecithin:retinol acyltransferase. Vitamin A uptake is regulated by all-trans-retinoic acid in nonocular tissues of mice. When in excess, vitamin A is rapidly taken up and converted to its inert ester form in peripheral tissues, such as lung, whereas in vitamin A deficiency, ocular retinoid uptake is favored | Mus musculus |