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Literature summary for 2.3.1.135 extracted from

  • Trevino, S.G.; Schuschereba, S.T.; Bowman, P.D.; Tsin, A.
    Lecithin:retinol acyltransferase in ARPE-19 (2005), Exp. Eye Res., 80, 897-900.
    View publication on PubMed
Search for more literature for 2.3.1.135

Application

Application Comment Organism
analysis ARPE-19 cell system is appropriate for studying the visual cycle enzymes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
retinyl bromoacetate 78% reduction of enzyme activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0095
-
 all-trans-retinol
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
 x * 25000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] Homo sapiens enzyme is involved in the visual cycle in the eye 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
no activity in Gallus gallus
-
 not found in glial cells
-

Source Tissue

Source Tissue Comment Organism Textmining
ARPE-19 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + all-trans-retinol
-
 Homo sapiens 2-acylglycerophosphocholine + all-trans-retinyl acylester
-
 ?
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein]
-
 Homo sapiens 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
 ?
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] enzyme is involved in the visual cycle in the eye Homo sapiens 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Subunits

Subunits Comment Organism
? x * 25000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
lecithin:retinol acyltransferase
-
 Homo sapiens
LRAT
-
 Homo sapiens