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Literature summary for 2.3.1.129 extracted from

  • Bhaskar, B.; Babu, T.; Rammohan, A.; Zheng, G.; Zyryanov, G.; Gu, W.
    Structure-based virtual screening of Pseudomonas aeruginosa Lpxa inhibitors using pharmacophore-based approach (2020), Biomolecules, 10, 266 .
    View publication on PubMed
Search for more literature for 2.3.1.129

Inhibitors

Inhibitors Comment Organism Structure
(3aR,10aR,13aR,20aR)-2,12-dimethyldecahydro-1H,10aH-[1,4,7,10,13,16]hexaoxacyclooctadecino[11,12-c:2,3-c']dipyrrole-1,3,11,13(2H,12H,13aH)-tetrone compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa
(3Z,5Z,7S,8S,9S,11Z,13E,15S,16S)-16-[(2R,3S,4R,6E,8S,9S)-3,9-dihydroxy-4,8-dimethyl-5-oxodec-6-en-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa
2-[[2-[(benzenesulfonyl)oxy]ethyl](phenyl)amino]ethyl 4-methylbenzene-1-sulfonate compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa
5-amino-4-hydroxy-3-[(E)-[8-hydroxy-6-(hydroxysulfonothioyl)-3-sulfonaphthalen-1-yl]diazenyl]naphthalene-2,7-disulfonic acid compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa
7-[3-([(2S)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino)propyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa
N-(2-hydroxyethyl)-N'-(2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin-15-yl)urea compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa
N-(2-[[(6-chloro-2H,4H-1,3-benzodioxin-8-yl)methyl]sulfanyl]phenyl)-N'-(3,4-dichlorophenyl)thiourea compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa
N1-(4,4-dihydroxybutyl)-N4-(2,2-dihydroxyethyl)benzene-1,4-disulfonamide compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa
tris[2-[2-(2-hydroxyethoxy)ethoxy]ethyl] phosphate compound identified using a complex-based pharmacophore model. Compound shows selective inhibition properties with essential residues in the pocket. The compound complies with the Lipinski rule showing no toxicity and drug likeness properties Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa A6V1E4
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Pseudomonas aeruginosa PA7 A6V1E4
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Synonyms

Synonyms Comment Organism
LpxA
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 Pseudomonas aeruginosa