Literature summary for 2.3.1.122 extracted from

Gahoi, S.; Mandal, R.S.; Ivanisenko, N.; Shrivastava, P.; Jain, S.; Singh, A.K.; Raghunandanan, M.V.; Kanchan, S.; Taneja, B.; Mandal, C.; Ivanisenko, V.A.; Kumar, A.; Kumar, R.; Open Source Drug Discovery Consortium; Ramachandran, S.
Computational screening for new inhibitors of M. tuberculosis mycolyltransferases antigen 85 group of proteins as potential drug targets (2012), J. Biomol. Struct. Dyn., 1, 30-43.

Search for more literature for 2.3.1.122

Application

Application	Comment	Organism
drug development	antigen 85 proteins are potential drug targets	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
ethyl 3-phenoxybenzyl butylphosphonate	-	Mycobacterium tuberculosis
additional information	inhibitor screening by molecular docking, overview	Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 alpha,alpha-trehalose 6-mycolate	Mycobacterium tuberculosis	-	alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 alpha,alpha-trehalose 6-mycolate	-	Mycobacterium tuberculosis	alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate	-	?

Synonyms

Synonyms	Comment	Organism
antigen 85C	-	Mycobacterium tuberculosis
mycolyltransferase	-	Mycobacterium tuberculosis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.002	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	ethyl 3-phenoxybenzyl butylphosphonate

General Information

General Information	Comment	Organism
physiological function	the enzyme is responsible for converting trehalose monomycolate to trehalose dimycolate, which contributes to cell wall stability	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)