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Literature summary for 2.3.1.122 extracted from

  • Gahoi, S.; Mandal, R.S.; Ivanisenko, N.; Shrivastava, P.; Jain, S.; Singh, A.K.; Raghunandanan, M.V.; Kanchan, S.; Taneja, B.; Mandal, C.; Ivanisenko, V.A.; Kumar, A.; Kumar, R.; Open Source Drug Discovery Consortium; Ramachandran, S.
    Computational screening for new inhibitors of M. tuberculosis mycolyltransferases antigen 85 group of proteins as potential drug targets (2012), J. Biomol. Struct. Dyn., 1, 30-43.
    View publication on PubMed

Application

Application Comment Organism
drug development antigen 85 proteins are potential drug targets Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
ethyl 3-phenoxybenzyl butylphosphonate
-
Mycobacterium tuberculosis
additional information inhibitor screening by molecular docking, overview Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 alpha,alpha-trehalose 6-mycolate Mycobacterium tuberculosis
-
alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 alpha,alpha-trehalose 6-mycolate
-
Mycobacterium tuberculosis alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate
-
?

Synonyms

Synonyms Comment Organism
antigen 85C
-
Mycobacterium tuberculosis
mycolyltransferase
-
Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
pH and temperature not specified in the publication Mycobacterium tuberculosis ethyl 3-phenoxybenzyl butylphosphonate

General Information

General Information Comment Organism
physiological function the enzyme is responsible for converting trehalose monomycolate to trehalose dimycolate, which contributes to cell wall stability Mycobacterium tuberculosis