Literature summary for 2.3.1.122 extracted from

Romano, M.; Roupie, V.; Wang, X.M.; Denis, O.; Jurion, F.; Adnet, P.; Laali, R.; Huygen, K.
Immunogenicity and protective efficacy of tuberculosis DNA vaccines combining mycolyl-transferase Ag85A and phosphate transport receptor PstS-3 (2006), Immunology, 118, 321-332.

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Application

Application	Comment	Organism
medicine	the enzyme is immunogenic in C57BL/6 mice and effective as tuberculosis vaccine, usage of vaccines combining mycolyl-transferase Ag85A and phosphate transport receptor PstS-3, overview	Mycobacterium tuberculosis variant bovis

Cloned(Commentary)

Cloned (Comment)	Organism
expression of Ag85A in baby hamster kidney cells and as His-tagged enzyme in Escherichia coli	Mycobacterium tuberculosis variant bovis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mycobacterium tuberculosis variant bovis	the enzyme, in form of DNA and protein or peptide fragments, is immunogenic in C57BL/6 mice and effective as tuberculosis vaccine against Mycobacterium tuberculosis strain H37Rv, alone and especially in combination with PstS3 DNA and/or protein, detailed overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis variant bovis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
native enzyme from strain BCG, recombinant enzyme from Escherichia coli	Mycobacterium tuberculosis variant bovis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme, in form of DNA and protein or peptide fragments, is immunogenic in C57BL/6 mice and effective as tuberculosis vaccine against Mycobacterium tuberculosis strain H37Rv, alone and especially in combination with PstS3 DNA and/or protein, detailed overview	Mycobacterium tuberculosis variant bovis	?	-	?

Synonyms

Synonyms	Comment	Organism
mycolyl-transferase Ag85A	-	Mycobacterium tuberculosis variant bovis

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Release 2023.1 (January 2023)