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Literature summary for 2.3.1.118 extracted from

  • Hein, D.; Doll, M.; Rustan, T.; Ferguson, R.
    Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions (1995), Cancer Res., 55, 3531-3536.
    View publication on PubMed
Search for more literature for 2.3.1.118

Cloned(Commentary)

Cloned (Comment) Organism
16 recombinant NAT2 allozymes expressed in Escherichia coli JM105 expression system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
paraoxon no significant effect Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33500
-
 SDS PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 radiolabel assay and Eadie-Hofstee plot Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 2-aminofluorene N-acetyltransferase activity Homo sapiens CoA + 2-acetylaminofluorene
-
 ?
acetyl-CoA + N-hydroxy-2-aminofluorene
-
 Homo sapiens CoA + N-acetoxy-2-aminofluorene
-
 ?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
-
 Homo sapiens CoA + N-acetoxy-4-aminobiphenyl
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 N-acetyltransferase assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 O-acetyltransferase assay Homo sapiens