Literature summary for 2.3.1.111 extracted from

Mathur, M.; Kolattokudy, P.E.
Molecular cloning and sequencing of the gene for mycocerosic acid synthase, a novel fatty acid elongating multifunctional enzyme, from Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin (1992), J. Biol. Chem., 267, 19388-19395.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
eicosanoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+	Mycobacterium tuberculosis	fatty acid biosynthesis	tetramethyl-branched mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	var. bovis Bacillus Calmette-Guerin	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
eicosanoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+	-	Mycobacterium tuberculosis	tetramethyl-branched mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O	-	?
eicosanoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+	fatty acid biosynthesis	Mycobacterium tuberculosis	tetramethyl-branched mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O	-	?

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Release 2023.1 (January 2023)