Literature summary for 2.3.1.108 extracted from

Lee, C.; Cheng, Y.; Chang, C.; Lin, C.; Chang, J.
Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption (2018), Sci. Rep., 8, 17477 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q5SQI0	-	-

Synonyms

Synonyms	Comment	Organism
ATAT1	-	Homo sapiens
Mec-17	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	overexpression of MEC-17 in A-549 cells enhances the cell spreading area, suppresses pseudopods formation in a three-dimensional culture system, and inhibits cancer cell migratory and invasive ability and tumour metastasis by orthotopic lung cancer animal model. Morphological change and migration inhibition of cancer cells are accompanied by epithelial-mesenchymal transition repression, Golgi reorientation, and polarity disruption caused by alteration of Cdc42 activity via a decrease in Rho-GAP, ARHGAP21. A reduction in endogenous MEC-17 accelerates the pseudopods formation and epithelial-mesenchymal transition, and facilitates cell migration and invasion	Homo sapiens

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Release 2023.1 (January 2023)