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Literature summary for 2.3.1.108 extracted from

  • Morelli, G.; Even, A.; Gladwyn-Ng, I.; Le Bail, R.; Shilian, M.; Godin, J.D.; Peyre, E.; Hassan, B.A.; Besson, A.; Rigo, J.M.; Weil, M.; Brone, B.; Nguyen, L.
    p27Kip1 modulates axonal transport by regulating alpha-tubulin acetyltransferase 1 stability (2018), Cell Rep., 23, 2429-2442 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8K341
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Source Tissue

Source Tissue Comment Organism Textmining
neuron
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 Mus musculus
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General Information

General Information Comment Organism
physiological function protein p27Kip1 controls the transport of vesicles and organelles along the axon of mice cortical projection neurons in vitro. p27Kip1 stabilizes the alpha-tubulin acetyltransferase 1, thereby promoting the acetylation of microtubules. Cortical extracts isolated from P0 p27Kip1 KO mice show a reduced level of acetylated alpha-tubulin, and the protein level of Atat1 is reduced upon loss of p27Kip1 Mus musculus