Literature summary for 2.3.1.108 extracted from

Stoner, M.W.; Thapa, D.; Zhang, M.; Gibson, G.A.; Calderon, M.J.; St Croix, C.M.; Scott, I.
alpha-Lipoic acid promotes alpha-tubulin hyperacetylation and blocks the turnover of mitochondria through mitophagy (2016), Biochem. J., 473, 1821-1830 .

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Organism

Organism	UniProt	Comment	Textmining
Chlorocebus aethiops	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
COS-7 cell	-	Chlorocebus aethiops	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + [alpha-tubulin]-L-lysine40	-	Chlorocebus aethiops	CoA + [alpha-tubulin]-N6-acetyl-L-lysine40	-	?

General Information

General Information	Comment	Organism
physiological function	treatment of cells with alpha-lipoic acid, leads to the hyperacetylation of alpha-tubulin residue K40 in the cytosol. The acetylation is blocked by pharmacological inhibition of mitochondrial citrate export, is dependent on the alpha-tubulin acetyltransferase Atat, and is coupled to a loss in function of the cytosolic histone deacetylase, HDAC6	Chlorocebus aethiops

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Release 2023.1 (January 2023)