Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipopolysaccharide | macrophages challenged by bacterial lipopolysaccharides undergo extensive microtubule acetylation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RAW-264.7 cell | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | macrophages challenged by bacterial lipopolysaccharides undergo extensive microtubule acetylation. Suppression of lipopolysaccharide-induced microtubule acetylation by inactivating the tubulin acetyltransferase, MEC17, profoundly inhibits the induction of anti-inflammatory interlukin-10, a phenotype effectively reversed by an acetylation-mimicking alpha-tubulin mutant. Reversible microtubule acetylation is a kinase signaling modulator and a key component in the inflammatory response | Mus musculus |