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BRENDA support

Literature summary for 2.3.1.108 extracted from

  • Solinger, J.A.; Paolinelli, R.; Kloess, H.; Scorza, F.B.; Marchesi, S.; Sauder, U.; Mitsushima, D.; Capuani, F.; Stuerzenbaum, S.R.; Cassata, G.
    The Caenorhabditis elegans elongator complex regulates neuronal alpha-tubulin acetylation (2010), PLoS Genet., 6, e1000820.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.108

Protein Variants

Protein Variants Comment Organism
additional information in an mec-12(e1607) background, i.e. a putative null mutant, acetylation of microtubules is absent in all developmental stages Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
elongator
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function elongator, a GTPase component of the hyperphosphorylated holoenzyme RNA polymerase II, is a regulator of alpha-tubulin acetylation in vivo. Elongator is important for microtubule function in correct loading and velocity of vesicles in vivo, and acetylation has a function in fine-tuning intrinsic dynamics of microtubules by modulating alpha-tubulin turnover Caenorhabditis elegans