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Literature summary for 2.3.1.107 extracted from

  • Dutta, A.; Batra, J.; Pandey-Rai, S.; Singh, D.; Kumar, S.; Sen, J.
    Expression of terpenoid indole alkaloid biosynthetic pathway genes corresponds to accumulation of related alkaloids in Catharanthus roseus (L.) G. Don (2005), Planta, 220, 376-383.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene Dat, DNA sequence determination and analysis Catharanthus roseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + deacetylvindoline Catharanthus roseus last step in alkaloid vindoline biosynthesis, vindoline is reacted to vinblastine and vincristine, pathway overview CoA + vindoline
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 ?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus Q9ZTK5 cultivars Nirmal, Prabal, and Dhawal, the mutants gsr-3 and gsr-6, and 1 horticultural variety Pacifica blush
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Source Tissue

Source Tissue Comment Organism Textmining
leaf
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 Catharanthus roseus
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additional information Dat gene expression profile analysis in cultivars Nirmal, Prabal, and Dhawal, the mutants gsr-3 and gsr-6, and 1 horticultural variety Pacifica blush, overview, not in root Catharanthus roseus
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seedling
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 Catharanthus roseus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + deacetylvindoline
-
 Catharanthus roseus CoA + vindoline
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 ?
acetyl-CoA + deacetylvindoline last step in alkaloid vindoline biosynthesis, vindoline is reacted to vinblastine and vincristine, pathway overview Catharanthus roseus CoA + vindoline
-
 ?

Synonyms

Synonyms Comment Organism
DAT
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 Catharanthus roseus
deacetyl vindoline 4-O-acetyl transferase
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 Catharanthus roseus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
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 Catharanthus roseus