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Literature summary for 2.2.1.8 extracted from
- In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: application of the fluorinase (2008), Chem. Biol., 15, 1268-1276.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli BL21, transfection to Streptococcus lividans TK24 | Streptomyces cattleya |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-threonine + fluoroacetaldehyde | Streptomyces cattleya | - |
4-fluoro-L-threonine + acetaldehyde | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces cattleya | B6VP39 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially by Ni-affinity column, size exclusion chromatography | Streptomyces cattleya |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-threonine + fluoroacetaldehyde | - |
Streptomyces cattleya | 4-fluoro-L-threonine + acetaldehyde | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 4-fluorothreoinine transaldolase | - |
Streptomyces cattleya |
| 4-FTase | - |
Streptomyces cattleya |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Streptomyces cattleya |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Streptomyces cattleya | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | final step of 4-fluorothreonine biosynthesis | Streptomyces cattleya |
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Release 2023.1 (January 2023)
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