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Literature summary for 2.2.1.7 extracted from
- Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase (2002), Glycobiology, 12, 813-820.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Mycobacterium tuberculosis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0061 | - |
D-glyceraldehyde 3-phosphate | pH 7.9, 37°C | Mycobacterium tuberculosis |  |
| 0.04 | - |
pyruvate | pH 7.9, 37°C | Mycobacterium tuberculosis | |
| 0.12 | - |
D-erythrose 4-phosphate | pH 7.9, 37°C | Mycobacterium tuberculosis | |
| 4.5 | - |
L-glyceraldehyde | pH 7.9, 37°C | Mycobacterium tuberculosis | |
| 5.6 | - |
D-glyceraldehyde | pH 7.9, 37°C | Mycobacterium tuberculosis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mycobacterium tuberculosis | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | divalent cation required, optimal concentration: 0.5-1 mM | Mycobacterium tuberculosis | |
| Mn2+ | divalent cation required | Mycobacterium tuberculosis | |
| Zn2+ | divalent cation required, supports activity to a lower level than Mn2+ or Mg2+ | Mycobacterium tuberculosis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate + D-erythrose 4-phosphate | - |
Mycobacterium tuberculosis | 1-deoxy-D-fructose 6-phosphate + CO2 | - |
? | |
| pyruvate + D-glyceraldehyde | - |
Mycobacterium tuberculosis | 1-deoxy-D-xylulose + CO2 | - |
? | |
| pyruvate + D-glyceraldehyde 3-phosphate | - |
Mycobacterium tuberculosis | 1-deoxy-D-xylulose 5-phosphate + CO2 | - |
? | |
| pyruvate + D-ribose 5-phosphate | - |
Mycobacterium tuberculosis | 1-deoxy-D-sedoheptulose 7-phosphate + CO2 | - |
? | |
| pyruvate + L-glyceraldehyde | - |
Mycobacterium tuberculosis | 1-deoxy-D-xylulose + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DXS | - |
Mycobacterium tuberculosis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thiamine diphosphate | required, Kd: 0.001 M, optimal concentration: 0.005-0.01 mM | Mycobacterium tuberculosis | |
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