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Literature summary for 2.2.1.6 extracted from

  • Lonhienne, T.; Garcia, M.D.; Pierens, G.; Mobli, M.; Nouwens, A.; Guddat, L.W.
    Structural insights into the mechanism of inhibition of AHAS by herbicides (2018), Proc. Natl. Acad. Sci. USA, 115, E1945-E1954 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.2.1.6

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with penoxsulam, hanging drop vapor diffusion method, using 1.0 M succinic acid, pH 7.0, 0.1 M HEPES, pH 7.0, and 1% (w/v) PEG monomethyl ether 2000 Arabidopsis thaliana
in complex with penoxsulam, hanging drop vapor diffusion method, using 1.0 M succinic acid, pH 7.0, 0.1 M HEPES, pH 7.0, and 1% (w/v) PEG monomethyl ether 2000 Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
penoxsulam
-
 Arabidopsis thaliana
penoxsulam 95% inhibition after 40 min at 0.002 mM Saccharomyces cerevisiae
propoxycarbazone
-
 Arabidopsis thaliana
propoxycarbazone
-
 Saccharomyces cerevisiae
thiencarbazone methyl
-
 Arabidopsis thaliana
thiencarbazone methyl 94% inhibition after 60 min at 0.002 mM Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 pyruvate Arabidopsis thaliana
-
 2-acetolactate + CO2
-
 ?
2 pyruvate Saccharomyces cerevisiae
-
 2-acetolactate + CO2
-
 ?
pyruvate + 2-oxobutyrate Arabidopsis thaliana
-
 2-aceto-2-hydroxybutyrate + CO2
-
 ?
pyruvate + 2-oxobutyrate Saccharomyces cerevisiae
-
 2-aceto-2-hydroxybutyrate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P17597
-
-
Saccharomyces cerevisiae P07342
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 pyruvate
-
 Arabidopsis thaliana 2-acetolactate + CO2
-
 ?
2 pyruvate
-
 Saccharomyces cerevisiae 2-acetolactate + CO2
-
 ?
pyruvate + 2-oxobutyrate
-
 Arabidopsis thaliana 2-aceto-2-hydroxybutyrate + CO2
-
 ?
pyruvate + 2-oxobutyrate
-
 Saccharomyces cerevisiae 2-aceto-2-hydroxybutyrate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
acetohydroxyacid synthase
-
 Arabidopsis thaliana
acetohydroxyacid synthase
-
 Saccharomyces cerevisiae
AHAS
-
 Arabidopsis thaliana
AHAS
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Arabidopsis thaliana
FAD
-
 Saccharomyces cerevisiae
thiamine diphosphate
-
 Arabidopsis thaliana
thiamine diphosphate
-
 Saccharomyces cerevisiae