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Literature summary for 2.2.1.6 extracted from

  • Yamato, S.; Sada, Y.; Ikeda, H.
    Characterization of acetolactate synthase from sulfonylurea herbicide-resistant Schoenoplectus juncoides (2013), Weed Biol. Manag., 13, 104-113.
No PubMed abstract available
Search for more literature for 2.2.1.6

Cloned(Commentary)

Cloned (Comment) Organism
gene ALS1 Schoenoplectiella juncoides
gene ALS2 Schoenoplectiella juncoides

Protein Variants

Protein Variants Comment Organism
P197S naturally occuring mutation leading to resistance against the sulfonylurea herbicide imazosulfuron Schoenoplectiella juncoides
P197S the mutant shows increased resistance against imazosulfuron Schoenoplectiella juncoides
P197T naturally occuring mutation leading to resistance against the sulfonylurea herbicide imazosulfuron Schoenoplectiella juncoides
P197T the mutant shows increased resistance against imazosulfuron Schoenoplectiella juncoides
W574L naturally occuring mutation leading to resistance against the sulfonylurea herbicide imazosulfuron Schoenoplectiella juncoides
W574L the mutant shows increased resistance against imazosulfuron Schoenoplectiella juncoides

Inhibitors

Inhibitors Comment Organism Structure
imazosulfuron 60-80% inhibition at 0.1-100 mM imazosulfuron; no or poor inhibition of resistant mutant enzyme, IC50 values in different plant accessions, overview; no or poor inhibition of resistant mutant enzyme, IC50 values in different plant accessions, overview Schoenoplectiella juncoides

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Schoenoplectiella juncoides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 pyruvate Schoenoplectiella juncoides
-
 2-acetolactate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Schoenoplectiella juncoides
-
-
-
Schoenoplectiella juncoides Q14TG2 ALS2; a sulfonylurea herbicide-resistant population collected from paddy fields in Japan, different accessions, gene ALS2
-
Schoenoplectiella juncoides Q14TG4 ALS1; a sulfonylurea herbicide-resistant population collected from paddy fields in Japan, different accessions, gene ALS1
-

Source Tissue

Source Tissue Comment Organism Textmining
shoot
-
 Schoenoplectiella juncoides
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 pyruvate
-
 Schoenoplectiella juncoides 2-acetolactate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
acetohydroxy acid synthase
-
 Schoenoplectiella juncoides
ALS
-
 Schoenoplectiella juncoides
ALS1 isoform Schoenoplectiella juncoides
ALS2 isoform Schoenoplectiella juncoides

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Schoenoplectiella juncoides

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Schoenoplectiella juncoides
thiamine diphosphate
-
 Schoenoplectiella juncoides
thiamine diphosphate dependent on Schoenoplectiella juncoides

General Information

General Information Comment Organism
malfunction the sulfonylurea-resistant plants, found in a population from paddy fields in Japan, harbor amino acid substitutions at Pro197 or Trp574 in either ALS1 or ALS2 (the amino acid number is standardized to the Arabidopsis thaliana sequence) Schoenoplectiella juncoides