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Literature summary for 2.2.1.5 extracted from

  • Sidhu, H.; Gupta, R.; Thind, S.K.; Nath, R.
    Oxalate metabolism in thiamine-deficient rats (1987), Ann. Nutr. Metab., 31, 354-361.
    View publication on PubMed
Search for more literature for 2.2.1.5

Application

Application Comment Organism
medicine involved in renal stone formation, decreased activity due to thiamine deficiency may increase oxalate excretion by 35% Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 rat
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 thiamine deficiency decreases specific activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + glyoxylate
-
 Rattus norvegicus 2-hydroxy-3-oxohexandioate + CO2
-
 ?

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate deficiency may lead to hyperoxaluria and glyoxylate excretion Rattus norvegicus