Literature summary for 2.2.1.15 extracted from

Liu, J.; Wei, Y.; Ma, K.; An, J.; Liu, X.; Liu, Y.; Ang, E.; Zhao, H.; Zhang, Y.
Mechanistically diverse pathways for sulfoquinovose degradation in bacteria (2021), ACS Catal., 11, 14740-14750 .

No PubMed abstract available

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde-3-phosphate	Clostridium sp. MSTE9	-	D-xylulose-5-phosphate + sulfoacetaldehyde	-	?
6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde-3-phosphate	Clostridium sp. MSTE9	-	D-xylulose-5-phosphate + 4-deoxy-4-sulfo-D-erythrose	-	?

Organism

Organism	UniProt	Comment	Textmining
Clostridium sp. MSTE9	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde-3-phosphate	-	Clostridium sp. MSTE9	D-xylulose-5-phosphate + sulfoacetaldehyde	-	?
6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde-3-phosphate	-	Clostridium sp. MSTE9	D-xylulose-5-phosphate + 4-deoxy-4-sulfo-D-erythrose	-	?

Synonyms

Synonyms	Comment	Organism
sqwGH	-	Clostridium sp. MSTE9

General Information

General Information	Comment	Organism
evolution	in diverse anaerobic bacteria including Firmicutes, Tenericutes, Spirochaetes, and Thermotogae bacteria, a sulfoquinone degradation pathway contains a mutarotase SqvB, an isomerase SqvD, a transketolase SqwGH, a homologue of ribose-5-phosphate isomerase SqwI, a metal-dependent alcohol dehydrogenase SqwF, and a member of the sulfite/sulfonate exporter family SqwE. This suggests a pathway involving isomerization of sulfoquinone to 6-deoxy-6-sulfofructose by SqvD, cleavage of 6-deoxy-6-sulfofructose by SqwGH, reduction of an aldehyde-containing sulfonate by SqwF, followed by export of the sulfonate end-product by SqwE	Clostridium sp. MSTE9

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Release 2023.1 (January 2023)