Literature summary for 2.2.1.1 extracted from

Ricciardelli, C.; Lokman, N.A.; Cheruvu, S.; Tan, I.A.; Ween, M.P.; Pyragius, C.E.; Ruszkiewicz, A.; Hoffmann, P.; Oehler, M.K.
Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation (2015), Clin. Exp. Metastasis, 32, 441-455 .

Search for more literature for 2.2.1.1

Application

Application	Comment	Organism
medicine	high nuclear enzyme positivity in peritoneal metastases is significantly associated with reduced overall survival and a 2.8fold increased risk of ovarian cancer death	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
oxythiamine	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LP-9 cell	-	Homo sapiens	-
OV-90 cell	-	Homo sapiens	-
ovarian serous carcinoma cell	-	Homo sapiens	-
ovary cancer cell	-	Homo sapiens	-
OVCA-5 cell	-	Homo sapiens	-
OVCAR-3 cell	-	Homo sapiens	-
peritoneal cancer cell	-	Homo sapiens	-
primary cell	-	Homo sapiens	-
SKOV-3 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TKT	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is upregulated in metastatic peritoneal implants	up

General Information

General Information	Comment	Organism
physiological function	the enzyme plays an important role in the proliferation of metastatic ovarian cancer cells	Homo sapiens

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Release 2023.1 (January 2023)