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Literature summary for 2.2.1.1 extracted from
- Function of the pentose phosphate pathway and its key enzyme, transketolase, in the regulation of the meiotic cell cycle in oocytes (2012), Clin. Exp. Reprod. Med., 39, 58-67.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| oocyte | enzyme is highly expressed at 2 hours of spontaneous maturation in oocytes | Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | evaluation of the loss-of-function results of transketolase by microinjection of transketolase double-stranded RNAs into germinal vesicle -stage oocytes, and culture of the oocytes in vitro. Despite the complete and specific knockdown of transketolase expression, germinal vesical breakdown occurred and meiosis was arrested at the metaphase I stage. The arrested oocytes exhibit spindle loss, chromosomal aggregation, and declined maturation promoting factor and mitogen-activated protein kinase activities. Transketolase and its associated pentose phosphate pathway play an important role in the MI-MII transition of the oocytes' meiotic cell cycle, but not in the process of germinal vesical breakdown | Mus musculus |
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Release 2023.1 (January 2023)
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