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Literature summary for 2.2.1.1 extracted from

  • Zhao, Y.; Pan, X.; Zhao, J.; Wang, Y.; Peng, Y.; Zhong, C.
    Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency (2009), J. Neurochem., 111, 537-546.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Mus musculus
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cerebral cortex thiamine-deficinet diet reduces transketolase activity in both cortex and hippocampus, without significantly affecting the activities of pyruvate dehydrogenase, alpha-ketoglutamate dehydrogenase, and glucose 6-phosphate dehydrogenase Mus musculus
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hippocampus thiamine-deficient diet reduces transketolase activity in both cortex and hippocampus, without significantly affecting the activities of pyruvate dehydrogenase, alpha-ketoglutamate dehydrogenase, and glucose 6-phosphate dehydrogenase Mus musculus
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General Information

General Information Comment Organism
physiological function transketolase silencing inhibits the proliferation, growth, and migratory abilities of cultured hippocampal progenitor cells, without affecting neuritogenesis of culture hippocampal neurons Mus musculus