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Literature summary for 2.2.1.1 extracted from

  • Kohrenhagen, N.; Voelker, H.U.; Schmidt, M.; Kapp, M.; Krockenberger, M.; Frambach, T.; Dietl, J.; Kammerer, U.
    Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia (2008), J. Obstet. Gynaecol. Res., 34, 293-300.
    View publication on PubMed
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Application

Application Comment Organism
medicine both TKTL1 and p-Akt play an important role in the progression of cervical neoplasia, which may be due to their impact on glycolysis. Intensity of the expression of TKTL1 and the oncogene p-Akt increases significantly with an increase in the histopathological grade of cervical tissues. TKTL1 and p-Akt can be possibly valuable targets for nontoxic antitumor therapeutic approaches, especially in cervical precancerous lesions and cancer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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 Homo sapiens 5737
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Organism

Organism UniProt Comment Textmining
Homo sapiens P51854
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Source Tissue

Source Tissue Comment Organism Textmining
cervical cell line
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 Homo sapiens
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additional information LGSIL cell, low-grade squamous intraepithelial lesions, low expression of TKTL1. HGSIL cell, high-grade squamous intraepithelial lesions, high expression of TKTL1. ISCC cell, invasive squamous cell carcinomas, highest expression of TKTL1 Homo sapiens
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Synonyms

Synonyms Comment Organism
TKTL1
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 Homo sapiens
transketolase-like 1
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 Homo sapiens
transketolase-like enzyme 1
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 Homo sapiens