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Literature summary for 2.2.1.1 extracted from

  • Chen, B.H.; Baganz, F.; Woodley, J.M.
    Modelling and optimization of a transketolase-mediated carbon-carbon bond formation reaction (2007), Chem. Eng. Sci., 62, 3178-3184.
No PubMed abstract available

Application

Application Comment Organism
additional information development of a comprehensive reaction model for a transketolase mediated carbon-carbon formation, based on the synthesis of erythrulose, which includes component degradation as a function of time and concentration as well as glycolaldehyde toxicity towards the enzyme and which can perform detailed simulations and link bioconversion to upstream fermentation and downstream product purification to determine optimal operating strategies to minimise process costs synthetic construct

Inhibitors

Inhibitors Comment Organism Structure
glycolaldehyde
-
synthetic construct

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
synthetic construct

Organism

Organism UniProt Comment Textmining
synthetic construct
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-hydroxypyruvate + glycolaldehyde
-
synthetic construct L-erythrulose + CO2
-
?

pH Range

pH Minimum pH Maximum Comment Organism
7 9
-
synthetic construct

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
synthetic construct