Literature summary for 2.2.1.1 extracted from

Voelker, H.U.; Hagemann, C.; Coy, J.; Wittig, R.; Sommer, S.; Stojic, J.; Haubitz, I.; Vince, G.H.; Kaemmerer, U.; Monoranu, C.M.
Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas (2008), Am. J. Clin. Pathol., 130, 50-57.

Search for more literature for 2.2.1.1

Application

Application	Comment	Organism
medicine	upregulation of TKTL1 in the metabolism of astrocytic gliomas with different degrees of malignancy. Percentage of positive cells for TKTL1 and p-Akt are significantly correlated. These observations can lead to additional therapeutic options targeting a specific blockade of TKTL1 enzyme activity	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
60000	-	smaller splice variant, Western blot analysis	Homo sapiens
70000	-	larger splice variant, Western blot analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P51854	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
glioblastoma multiforme cell	compared with grades II and III astrocytic gliomas, glioblastoma multiformes show higher expression of TKTL1	Homo sapiens	-
additional information	TKTL1 is significantly overexpressed in tumors of astrocytic gliomas. Tumor grade significantly correlates with expression of TKTL1	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TKTL1	-	Homo sapiens
transketolase-like 1	-	Homo sapiens

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Release 2023.1 (January 2023)