Literature summary for 2.1.4.1 extracted from

Braissant, O.; Cagnon, L.; Monnet-Tschudi, F.; Speer, O.; Wallimann, T.; Honegger, P.; Henry, H.
Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency (2008), Eur. J. Neurosci., 27, 1673-1685.

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Application

Application	Comment	Organism
medicine	reaggregated brain cell three-dimensional cultures exposed to NH4Cl are used as an experimental model of hyperammonemia in the developing central nervous system	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
NH4+	NH4+-induced decrease in creatine and guanidinoacetate probably occurs through inhibition of AGAT enzymatic activity	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-arginine + glycine	Rattus norvegicus	-	L-ornithine + guanidinoacetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P50442	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Rattus norvegicus	-
brain	-	Rattus norvegicus	-
glial cell	-	Rattus norvegicus	-
neuron	-	Rattus norvegicus	-
oligodendrocyte	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-arginine + glycine	-	Rattus norvegicus	L-ornithine + guanidinoacetate	-	?

Synonyms

Synonyms	Comment	Organism
AGAT	-	Rattus norvegicus
arginine:glycine amidinotransferase	-	Rattus norvegicus
glycine amidinotransferase	-	Rattus norvegicus

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Release 2023.1 (January 2023)