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Literature summary for 2.1.4.1 extracted from
- The purification and charcterization of human kidney L-arginine:glycine amidinotransferase (1986), Arch. Biochem. Biophys., 251, 747-755.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | presence of the enzyme in serum or urine may prove useful in development of kidney disease diagnosis, hyperornithinemia, an autosomal recessive disease caused by decreased enzyme activity, enzyme activity is also dimished in thyrotoxicosis and myotonic muscular dystrophy | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.3 | - |
arginine | - |
Sus scrofa |  |
| 2.4 | - |
arginine | beta-transamidinase | Rattus norvegicus | |
| 2.5 | - |
glycine | - |
Homo sapiens | |
| 2.5 | - |
arginine | - |
Homo sapiens | |
| 2.8 | - |
arginine | alpha-transamidinase | Rattus norvegicus | |
| 3 | - |
glycine | alpha-transamidinase | Rattus norvegicus | |
| 3.1 | - |
glycine | beta-transamidinase | Rattus norvegicus | |
| 18 | - |
glycine | - |
Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42000 | - |
2 * 42000, alpha-transamidinase, SDS-PAGE, 2 * 44000, beta-transamidinase, SDS-PAGE | Rattus norvegicus |
| 44000 | - |
2 * 44000, SDS-PAGE | Homo sapiens |
| 44000 | - |
2 * 42000, alpha-transamidinase, SDS-PAGE, 2 * 44000, beta-transamidinase, SDS-PAGE | Rattus norvegicus |
| 82600 | - |
alpha-transamidinase, sedimentation equilibrium | Rattus norvegicus |
| 83300 | - |
beta-transamidinase, sedimentation equilibrium | Rattus norvegicus |
| 89000 | - |
gel filtration, equilibrium sedimentation | Homo sapiens |
| 100000 | - |
- |
Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginine + glycine | Homo sapiens | - |
L-ornithine + guanidinoacetate | - |
r | |
| L-arginine + glycine | Rattus norvegicus | - |
L-ornithine + guanidinoacetate | - |
r | |
| L-arginine + glycine | Sus scrofa | - |
L-ornithine + guanidinoacetate | - |
r | |
| L-ornithine + guanidinoacetate | Sus scrofa | - |
L-arginine + glycine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
rat | - |
| Sus scrofa | - |
pig, porcine, hog | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Sus scrofa | - |
| kidney | - |
Sus scrofa | - |
| liver | - |
Sus scrofa | - |
| muscle | - |
Sus scrofa | - |
| pancreas | - |
Sus scrofa | - |
| proximal tubule | - |
Homo sapiens | - |
| proximal tubule | - |
Rattus norvegicus | - |
| spleen | - |
Homo sapiens | - |
| spleen | - |
Rattus norvegicus | - |
| spleen | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.25 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| canavanine + ornithine | - |
Homo sapiens | arginine + canaline | - |
r | |
| canavanine + ornithine | - |
Rattus norvegicus | arginine + canaline | - |
r | |
| canavanine + ornithine | - |
Sus scrofa | arginine + canaline | - |
r | |
| L-arginine + glycine | - |
Homo sapiens | L-ornithine + guanidinoacetate | - |
r | |
| L-arginine + glycine | - |
Rattus norvegicus | L-ornithine + guanidinoacetate | - |
r | |
| L-arginine + glycine | - |
Sus scrofa | L-ornithine + guanidinoacetate | - |
r | |
| L-ornithine + guanidinoacetate | - |
Sus scrofa | L-arginine + glycine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Sus scrofa |
| dimer | 2 * 44000, SDS-PAGE | Homo sapiens |
| dimer | 2 * 42000, alpha-transamidinase, SDS-PAGE, 2 * 44000, beta-transamidinase, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Sus scrofa |
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