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Literature summary for 2.1.3.3 extracted from

  • Sankaranarayanan, R.; Cherney, M.M.; Cherney, L.T.; Garen, C.R.; Moradian, F.; James, M.N.
    The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzymes catalytic mechanism (2008), J. Mol. Biol., 375, 1052-1063.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, crystal structures of Mtb OTC in orthorhombic and hexagonal form hexagonal form crystals complexed with carbamoyl phosphate and L-norvaline Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
L-norvaline competitive Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
3 * 33000, crystal structure analysis Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoyl phosphate + L-ornithine Mycobacterium tuberculosis catalyzes the sixth step in arginine biosynthesis phosphate + citrulline
-
r
carbamoyl phosphate + L-ornithine Mycobacterium tuberculosis H37Rv catalyzes the sixth step in arginine biosynthesis phosphate + citrulline
-
r

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WIT9
-
-
Mycobacterium tuberculosis H37Rv P9WIT9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine catalyzes the sixth step in arginine biosynthesis Mycobacterium tuberculosis phosphate + citrulline
-
r
carbamoyl phosphate + L-ornithine catalyzes the sixth step in arginine biosynthesis Mycobacterium tuberculosis H37Rv phosphate + citrulline
-
r

Subunits

Subunits Comment Organism
hexamer crystal structure analysis, possibly a crystallization artifact Mycobacterium tuberculosis
trimer 3 * 33000, crystal structure analysis Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
Mtb OTC
-
Mycobacterium tuberculosis