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Literature summary for 2.1.3.15 extracted from

  • Keereetaweep, J.; Liu, H.; Zhai, Z.; Shanklin, J.
    Biotin attachment domain-containing proteins irreversibly inhibit acetyl CoA carboxylase (2018), Plant Physiol., 177, 208-215 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.3.15

Inhibitors

Inhibitors Comment Organism Structure
additional information incorporation of biotin attachment domain-containing proteins (inactive analogs of biotin carboxyl transfer proteins that lack biotin) into the enzyme down-regulates its activity by displacing active (biotin-containing) biotin carboxyltransferase protein subunits Arabidopsis thaliana
oleic acid irreversible enzyme inhibition Arabidopsis thaliana
Tween 80 reversible enzyme inhibition at 10 mM Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA Arabidopsis thaliana
-
 [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
-
 Arabidopsis thaliana [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACCase
-
 Arabidopsis thaliana
Acetyl CoA carboxylase
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
biotin dependent on Arabidopsis thaliana