Inhibitors | Comment | Organism | Structure |
---|---|---|---|
citrate | - |
Sus scrofa | |
folic acid | - |
Sus scrofa | |
imidazole | - |
Sus scrofa | |
L-glutamate | product inhibition | Sus scrofa | |
Maleate | - |
Sus scrofa | |
N-formiminoaspartate | - |
Sus scrofa | |
Tris | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
tetrahydrofolate | - |
Sus scrofa | |
2 | - |
N-formimino-L-glutamate | tetrahydropteroic acid as substrate | Sus scrofa | |
2.5 | - |
tetrahydropteroic acid | - |
Sus scrofa | |
12 | - |
N-formimino-L-glutamate | tetrahydrofolate as substrate | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-formiminoglutamate + tetrahydrofolate | Sus scrofa | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate | mechanism | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
43 | 45 | - |
Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | molecular enzyme complex with formiminotransferase and cyclodeaminase activity, EC 2.1.2.5 and EC 4.3.1.4, both activities are contained in a single polypeptide chain, no substrate: formiminoaspartate | Sus scrofa | ? | - |
? | |
N-formiminoglutamate + tetrahydrofolate | histidine degradation | Sus scrofa | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
tetrahydrofolate + N-formimino-L-glutamate | tetrahydropteroic acid can replace tetrahydrofolate | Sus scrofa | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
tetrahydropteroic acid + N-formimino-L-glutamate | tetrahydropteroic acid is a good alternate substrate | Sus scrofa | 5-formiminotetrahydropteroic acid + L-glutamate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homooctamer | - |
Sus scrofa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Sus scrofa |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | 26000 per min per mol or 3250 per min per chain | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrofolate | folate-dependent enzyme | Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
folic acid | - |
Sus scrofa | |
0.9 | - |
L-glutamate | - |
Sus scrofa | |
4 | - |
Tris | - |
Sus scrofa | |
6 | - |
imidazole | - |
Sus scrofa | |
10 | - |
formiminoaspartate | - |
Sus scrofa | |
30 | - |
Maleate | - |
Sus scrofa | |
60 | - |
citrate | - |
Sus scrofa |