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Literature summary for 2.1.2.5 extracted from

  • Beaudet, R.; Mackenzie, R.
    Kinetic mechanism of formininotransferase from porcine liver (1975), Biochim. Biophys. Acta, 410, 252-261.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
citrate
-
Sus scrofa
folic acid
-
Sus scrofa
imidazole
-
Sus scrofa
L-glutamate product inhibition Sus scrofa
Maleate
-
Sus scrofa
N-formiminoaspartate
-
Sus scrofa
Tris
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
tetrahydrofolate
-
Sus scrofa
2
-
N-formimino-L-glutamate tetrahydropteroic acid as substrate Sus scrofa
2.5
-
tetrahydropteroic acid
-
Sus scrofa
12
-
N-formimino-L-glutamate tetrahydrofolate as substrate Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-formiminoglutamate + tetrahydrofolate Sus scrofa histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate mechanism Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
43 45
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information molecular enzyme complex with formiminotransferase and cyclodeaminase activity, EC 2.1.2.5 and EC 4.3.1.4, both activities are contained in a single polypeptide chain, no substrate: formiminoaspartate Sus scrofa ?
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Sus scrofa 5-formiminotetrahydrofolate + L-glutamate
-
?
tetrahydrofolate + N-formimino-L-glutamate tetrahydropteroic acid can replace tetrahydrofolate Sus scrofa 5-formiminotetrahydrofolate + L-glutamate
-
?
tetrahydropteroic acid + N-formimino-L-glutamate tetrahydropteroic acid is a good alternate substrate Sus scrofa 5-formiminotetrahydropteroic acid + L-glutamate
-
?

Subunits

Subunits Comment Organism
homooctamer
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information 26000 per min per mol or 3250 per min per chain Sus scrofa

Cofactor

Cofactor Comment Organism Structure
tetrahydrofolate folate-dependent enzyme Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.1
-
folic acid
-
Sus scrofa
0.9
-
L-glutamate
-
Sus scrofa
4
-
Tris
-
Sus scrofa
6
-
imidazole
-
Sus scrofa
10
-
formiminoaspartate
-
Sus scrofa
30
-
Maleate
-
Sus scrofa
60
-
citrate
-
Sus scrofa