Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aminopterin | 0.0005 mM, 53% inhibition | Sus scrofa | |
barium acetate | 0.1 M, 90% inhibition | Sus scrofa | |
CaCl2 | 0.1 M, 72% inhibition | Sus scrofa | |
KCl | - |
Bos taurus | |
KCl | high concentrations | Sus scrofa | |
methotrexate | 0.0005 mM: 33% inhibition, 0.001 mM: 83% inhibition | Sus scrofa | |
MnCl2 | 0.1 M: 98% inhibition, 0.01 M: 65% inhibition | Sus scrofa | |
NH4Cl | high concentrations | Sus scrofa | |
ZnCl2 | 0.01 M, 99% inhibition | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
tetrahydrofolate | - |
Sus scrofa | |
11 | - |
N-formimino-L-glutamate | - |
Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
KCl | weak stimulation by low concentrations | Sus scrofa | |
NH4+ | NH4Cl: weak stimulation by low concentrations | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-formiminoglutamate + tetrahydrofolate | Cavia porcellus | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | Mus musculus | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | Homo sapiens | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | Sus scrofa | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | Bos taurus | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | Oryctolagus cuniculus | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | Felis catus | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Cavia porcellus | - |
- |
- |
Felis catus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
700fold purification | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | low activity | Cavia porcellus | - |
kidney | low activity | Mus musculus | - |
kidney | low activity | Sus scrofa | - |
kidney | low activity | Bos taurus | - |
kidney | low activity | Oryctolagus cuniculus | - |
kidney | low activity | Felis catus | - |
liver | - |
Cavia porcellus | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
liver | - |
Oryctolagus cuniculus | - |
liver | - |
Felis catus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Cavia porcellus |
additional information | - |
- |
Mus musculus |
additional information | - |
- |
Homo sapiens |
additional information | - |
- |
Sus scrofa |
additional information | - |
- |
Bos taurus |
additional information | - |
- |
Oryctolagus cuniculus |
additional information | - |
- |
Felis catus |
Storage Stability | Organism |
---|---|
-20°C, several weeks, stable | Sus scrofa |
2°C, 2 months, 16-45% loss of activity | Sus scrofa |
2°C, several weeks, stable | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3 | Sus scrofa | ? | - |
? | |
additional information | primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3 | Bos taurus | ? | - |
? | |
additional information | not: formiminoglycine, very poor substrates: formimino-L-aspartic acid, formyl-L-glutamic acid | Sus scrofa | ? | - |
? | |
N-formiminoglutamate + tetrahydrofolate | histidine degradation | Cavia porcellus | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | histidine degradation | Mus musculus | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | histidine degradation | Homo sapiens | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | histidine degradation | Sus scrofa | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | histidine degradation | Bos taurus | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | histidine degradation | Oryctolagus cuniculus | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
N-formiminoglutamate + tetrahydrofolate | histidine degradation | Felis catus | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
tetrahydrofolate + N-formimino-L-glutamate | - |
Cavia porcellus | 5-formiminotetrahydrofolate + L-glutamate | - |
r | |
tetrahydrofolate + N-formimino-L-glutamate | - |
Mus musculus | 5-formiminotetrahydrofolate + L-glutamate | - |
r | |
tetrahydrofolate + N-formimino-L-glutamate | - |
Homo sapiens | 5-formiminotetrahydrofolate + L-glutamate | - |
r | |
tetrahydrofolate + N-formimino-L-glutamate | - |
Bos taurus | 5-formiminotetrahydrofolate + L-glutamate | - |
r | |
tetrahydrofolate + N-formimino-L-glutamate | - |
Oryctolagus cuniculus | 5-formiminotetrahydrofolate + L-glutamate | - |
r | |
tetrahydrofolate + N-formimino-L-glutamate | - |
Felis catus | 5-formiminotetrahydrofolate + L-glutamate | - |
r | |
tetrahydrofolate + N-formimino-L-glutamate | relatively specific for formiminoglutamic acid | Sus scrofa | 5-formiminotetrahydrofolate + L-glutamate | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | - |
Sus scrofa |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.2 | 9 | about 50% of activity maximum at pH 6.2 and 9.0 | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrofolate | - |
Cavia porcellus | |
tetrahydrofolate | - |
Mus musculus | |
tetrahydrofolate | - |
Homo sapiens | |
tetrahydrofolate | - |
Sus scrofa | |
tetrahydrofolate | - |
Bos taurus | |
tetrahydrofolate | - |
Oryctolagus cuniculus | |
tetrahydrofolate | - |
Felis catus |