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Literature summary for 2.1.2.5 extracted from

  • Tabor, H.; Wyngarden, L.
    The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid (1959), J. Biol. Chem., 234, 1830-1846.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aminopterin 0.0005 mM, 53% inhibition Sus scrofa
barium acetate 0.1 M, 90% inhibition Sus scrofa
CaCl2 0.1 M, 72% inhibition Sus scrofa
KCl
-
Bos taurus
KCl high concentrations Sus scrofa
methotrexate 0.0005 mM: 33% inhibition, 0.001 mM: 83% inhibition Sus scrofa
MnCl2 0.1 M: 98% inhibition, 0.01 M: 65% inhibition Sus scrofa
NH4Cl high concentrations Sus scrofa
ZnCl2 0.01 M, 99% inhibition Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
tetrahydrofolate
-
Sus scrofa
11
-
N-formimino-L-glutamate
-
Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
KCl weak stimulation by low concentrations Sus scrofa
NH4+ NH4Cl: weak stimulation by low concentrations Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-formiminoglutamate + tetrahydrofolate Cavia porcellus histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate Mus musculus histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate Homo sapiens histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate Sus scrofa histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate Bos taurus histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate Oryctolagus cuniculus histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate Felis catus histidine degradation 5-formiminotetrahydrofolate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cavia porcellus
-
-
-
Felis catus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
700fold purification Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney low activity Cavia porcellus
-
kidney low activity Mus musculus
-
kidney low activity Sus scrofa
-
kidney low activity Bos taurus
-
kidney low activity Oryctolagus cuniculus
-
kidney low activity Felis catus
-
liver
-
Cavia porcellus
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Sus scrofa
-
liver
-
Bos taurus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Felis catus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Cavia porcellus
additional information
-
-
Mus musculus
additional information
-
-
Homo sapiens
additional information
-
-
Sus scrofa
additional information
-
-
Bos taurus
additional information
-
-
Oryctolagus cuniculus
additional information
-
-
Felis catus

Storage Stability

Storage Stability Organism
-20°C, several weeks, stable Sus scrofa
2°C, 2 months, 16-45% loss of activity Sus scrofa
2°C, several weeks, stable Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3 Sus scrofa ?
-
?
additional information primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3 Bos taurus ?
-
?
additional information not: formiminoglycine, very poor substrates: formimino-L-aspartic acid, formyl-L-glutamic acid Sus scrofa ?
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Cavia porcellus 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Mus musculus 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Homo sapiens 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Sus scrofa 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Bos taurus 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Oryctolagus cuniculus 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate histidine degradation Felis catus 5-formiminotetrahydrofolate + L-glutamate
-
?
tetrahydrofolate + N-formimino-L-glutamate
-
Cavia porcellus 5-formiminotetrahydrofolate + L-glutamate
-
r
tetrahydrofolate + N-formimino-L-glutamate
-
Mus musculus 5-formiminotetrahydrofolate + L-glutamate
-
r
tetrahydrofolate + N-formimino-L-glutamate
-
Homo sapiens 5-formiminotetrahydrofolate + L-glutamate
-
r
tetrahydrofolate + N-formimino-L-glutamate
-
Bos taurus 5-formiminotetrahydrofolate + L-glutamate
-
r
tetrahydrofolate + N-formimino-L-glutamate
-
Oryctolagus cuniculus 5-formiminotetrahydrofolate + L-glutamate
-
r
tetrahydrofolate + N-formimino-L-glutamate
-
Felis catus 5-formiminotetrahydrofolate + L-glutamate
-
r
tetrahydrofolate + N-formimino-L-glutamate relatively specific for formiminoglutamic acid Sus scrofa 5-formiminotetrahydrofolate + L-glutamate
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
6.2 9 about 50% of activity maximum at pH 6.2 and 9.0 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
tetrahydrofolate
-
Cavia porcellus
tetrahydrofolate
-
Mus musculus
tetrahydrofolate
-
Homo sapiens
tetrahydrofolate
-
Sus scrofa
tetrahydrofolate
-
Bos taurus
tetrahydrofolate
-
Oryctolagus cuniculus
tetrahydrofolate
-
Felis catus