Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | Caenorhabditis elegans | - |
tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Caenorhabditis elegans | Q95QQ4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
Caenorhabditis elegans | tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-aminoimidazole-4-carboxamideribonucleotide formyltransferase | - |
Caenorhabditis elegans |
AICAR-transformylase | - |
Caenorhabditis elegans |
AICAR-transformylase/IMP cyclohydrolase | - |
Caenorhabditis elegans |
AICARFT | - |
Caenorhabditis elegans |
ATIC | bifunational enzyme with AICAR-transformylase and IMP cyclohydrolase activities | Caenorhabditis elegans |
atic-1 | - |
Caenorhabditis elegans |
C55F2.1 | - |
Caenorhabditis elegans |
Organism | Comment | Expression |
---|---|---|
Caenorhabditis elegans | high glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions | up |
Caenorhabditis elegans | there is approximately 2.7fold increased enzyme expression at 5 days of high glucose (13 mM) compared with standard conditions (5 mM) | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine de novo synthesis. High glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions. Inhibition of atic-1 expression, by RNAi, under high glucose is associated with increased lifespan and head motility and reduced neuronal damage, reactive oxygen species, and methylglyoxal-derived advanced glycation end product accumulation. The enzyme (atic-1) is involved in glucotoxic effects under high glucose conditions, either by blocked atic-1 expression or via induction of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and AMP-activated kinase (AMPK) induction | Caenorhabditis elegans |
physiological function | enzyme overexpression decreases the median lifespan from 23.6 to 20.6 days compared with control nematodes under standard conditions | Caenorhabditis elegans |