Literature summary for 2.1.2.3 extracted from

Baggott, J.E.; Vaughn, W.H.; Hudson, B.B.
Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide (1986), Biochem. J., 236, 193-200.

Search for more literature for 2.1.2.3

Inhibitors

Inhibitors	Comment	Organism	Structure
10-formyl-5,6,7,8-tetrahydropteroylpenta-gamma-glutamate	-	Gallus sp.
10-formylfolic acid pentaglutamate	competitive inhibitor	Gallus sp.
4-amino-10-methylpteroyl-gamma-glutamyl-gamma-glutamyl-gamma-glutamylglutamic acid	methotrexate polyglutamate, competitive inhibitor	Gallus sp.
4-amino-10-methylpteroylglutamic acid	methotrexate, non-competitive inhibitor	Gallus sp.
5-amino-4-nitroimidazole ribonucleotide	-	Mus musculus
5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide	-	Mus musculus
7,8-dihydropteroylpenta-gamma-glutamate	-	Gallus sp.
dihydrofolic acid pentaglutamate	-	Gallus sp.
folic acid pentaglutamate	competitive inhibitor	Gallus sp.
methotrexate	-	Gallus sp.
pteroylpenta-gamma-glutamate	-	Gallus sp.

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00023	-	tetrahydrofolic acid	-	Gallus sp.
0.00051	-	10-formyldihydrofolic acid pentaglutamate	-	Gallus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide	Mus musculus	-	tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide	Gallus sp.	-	tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	r

Organism

Organism	UniProt	Comment	Textmining
Gallus sp.	-	chicken	-
Mus musculus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partially	Gallus sp.

Source Tissue

Source Tissue	Comment	Organism	Textmining
Ehrlich ascites carcinoma cell	-	Mus musculus	-
liver	-	Gallus sp.	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
10-formyl-7,8-dihydropteroylpenta-gamma-glutamate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide	-	Gallus sp.	7,8-dihydropteroylpenta-gamma-glutarate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	?
10-formyl-7,8-dihydropteroylpenta-gamma-L-glutamate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide	-	Gallus sp.	dihydrofolic acid pentaglutamate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	?
10-formyldihydrofolic acid pentaglutamate + 5-aminoimidazole-4-carboxamide	-	Gallus sp.	?	-	r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide	-	Mus musculus	tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide	-	Gallus sp.	tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	r
additional information	in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene	Mus musculus	?	-	?
additional information	in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene	Gallus sp.	?	-	?
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide	-	Mus musculus	tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide	-	r
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide	-	Gallus sp.	tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00004	-	5-amino-4-nitroimidazole ribonucleotide	-	Mus musculus
0.00007	-	5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide	-	Mus musculus
0.00008	-	folic acid pentaglutamate	-	Gallus sp.
0.00014	-	dihydrofolic acid pentaglutamate	-	Gallus sp.
0.00137	-	10-formylfolic acid pentaglutamate	-	Gallus sp.
0.00315	-	methotrexate polyglutamate	-	Gallus sp.
0.075	-	methotrexate	-	Gallus sp.

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)