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Literature summary for 2.1.2.2 extracted from

  • Cheng, H.; Chong, Y.; Hwang, I.; Tavassoli, A.; Zhang, Y.; Wilson, I.A.; Benkovic, S.J.; Boger, D.L.
    Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway (2005), Bioorg. Med. Chem., 13, 3577-3585.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
10-CF3CO-DDACTHF
-
 Homo sapiens
10-formyl-DDACTHF
-
 Homo sapiens
10-methanesulfonyl-5-DACTHF
-
 Homo sapiens
10-methanesulfonyl-DDACTHF
-
 Homo sapiens
10-methylthio-DDACTHF
-
 Homo sapiens
DDACTHF
-
 Escherichia coli
DDACTHF
-
 Homo sapiens
additional information 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF and 10-methylthio-DDACTHF shows KI-values above 0.1 mM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
 recombinant
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000014
-
 10-formyl-DDACTHF 26°C, pH 7.5 Homo sapiens
0.000015
-
 10-CF3CO-DDACTHF 26°C, pH 7.5 Homo sapiens
0.00023
-
 10-methanesulfonyl-DDACTHF 26°C, pH 7.5 Homo sapiens
0.00025
-
 10-methylthio-DDACTHF 26°C, pH 7.5 Homo sapiens
0.00058
-
 10-methanesulfonyl-5-DACTHF 26°C, pH 7.5 Homo sapiens
0.0017
-
 DDACTHF 26°C, pH 7.5 Homo sapiens
0.005
-
 DDACTHF 26°C, pH 7.5 Escherichia coli