Application | Comment | Organism |
---|---|---|
medicine | pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs | Mus musculus |
medicine | pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs | Escherichia coli |
medicine | pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
cloned by functional complementation in Escherichia coli | Homo sapiens |
cloning of a 12-gene cluster encoding 9 enzymes for de novo purine nucleotide synthesis | Bacillus subtilis |
Crystallization (Comment) | Organism |
---|---|
crystals grown by vapor diffusion, space group C222, a = 140.5 A, b = 98.2 A, c = 103.3 A | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,10-dideaza-5,6,7,8-tetrahydrofolate | - |
Escherichia coli | |
5,10-dideaza-5,6,7,8-tetrahydrofolate | - |
Homo sapiens | |
5,10-dideazatetrahydrofolate | - |
Escherichia coli | |
5,10-dideazatetrahydrofolate | - |
Homo sapiens | |
5,10-dideazatetrahydrofolate | - |
Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
23000 | - |
- |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Bacillus subtilis | - |
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Saccharomyces cerevisiae | - |
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Drosophila melanogaster | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Escherichia coli | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Homo sapiens | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + glycinamide ribonucleotide | Mus musculus | - |
tetrahydrofolate + formylglycinamide ribonucleotide | - |
? | |
10-formyltetrahydrofolate + glycinamide ribonucleotide | Escherichia coli | - |
tetrahydrofolate + formylglycinamide ribonucleotide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Drosophila melanogaster | - |
fruit fly | - |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse | - |
Saccharomyces cerevisiae | - |
yeast | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Drosophila melanogaster | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Bacillus subtilis | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Saccharomyces cerevisiae | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Drosophila melanogaster | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + glycinamide ribonucleotide | - |
Mus musculus | tetrahydrofolate + formylglycinamide ribonucleotide | - |
? | |
10-formyltetrahydrofolate + glycinamide ribonucleotide | - |
Escherichia coli | tetrahydrofolate + formylglycinamide ribonucleotide | - |
? | |
additional information | monofunctional enzyme | Bacillus subtilis | ? | - |
? | |
additional information | monofunctional enzyme | Escherichia coli | ? | - |
? | |
additional information | 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase | Mus musculus | ? | - |
? | |
additional information | 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Escherichia coli |
dimer | - |
Saccharomyces cerevisiae |