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Literature summary for 2.1.2.2 extracted from

  • Warren, L.; Buchanan, J.M.
    Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5'-phosphate(glycinamide ribotide) transformylase (1957), J. Biol. Chem., 229, 613-626.
    View publication on PubMed
Search for more literature for 2.1.2.2

Activating Compound

Activating Compound Comment Organism Structure
glycine stimulatory effect Gallus gallus
histidine stimulatory effect Gallus gallus
tryptophan stimulatory effect Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
 Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.052
-
 glycinamide ribotide
-
 Gallus gallus
0.058
-
 N5,N10-anhydroformyl tetrahydrofolate
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Clostridium cylindrosporum
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Columba sp.
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium cylindrosporum
-
-
-
Columba sp.
-
 pigeon
-
Gallus gallus
-
 chicken
-

Purification (Commentary)

Purification (Comment) Organism
-
 Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-
liver
-
 Columba sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
53.6
-
-
 Gallus gallus

Storage Stability

Storage Stability Organism
-10°C, 8months, no appreciable loss of activity Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Clostridium cylindrosporum tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Columba sp. tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
inosinic acid + glycinamide ribotide + H2O
-
 Gallus gallus 5-amino-4-imidazolecarboxamide ribotide + formylglycinamide ribotide
-
 ?
additional information reaction does not occur if glycine, glycinamide or glycinamide riboside is substituted for glycinamide ribotide Gallus gallus ?
-
 ?
N5,N10-anhydroformyl-5,6,7,8tetrahydrofolic acid + 2-amino-N-ribosylacetamide 5'-phosphate + H2O
-
 Gallus gallus formylglycinamide ribotide + tetrahydrofolic acid + 2-formamido-N-ribosylacetamide 5'-phosphate
-
 ir
N5,N10-anhydroformyltetrahydrofolate + glycinamide ribotide + H2O
-
 Clostridium cylindrosporum N10-formyltetrahydrofolate + formylglycinamide ribotide
-
 ?

Synonyms

Synonyms Comment Organism
2-amino-N-ribosylacetamide 5'-phosphate (glycinamide ribotide) transformylase
-
 Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 Tris buffer, 38°C Gallus gallus