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Literature summary for 2.1.1.B123 extracted from

  • Lee, K.W.; Bogenhagen, D.F.
    Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA) (2014), J. Biol. Chem., 289, 24936-24942 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + uridine1369 in 16S rRNA Homo sapiens
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 S-adenosyl-L-homocysteine + 2'-O-methyluridine1369 in 16S rRNA
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UI43
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + uridine1369 in 16S rRNA
-
 Homo sapiens S-adenosyl-L-homocysteine + 2'-O-methyluridine1369 in 16S rRNA
-
 ?

General Information

General Information Comment Organism
physiological function siRNA directed against MRM2 results in loss of methylation at at residue U1369 of 16S RNA and in a general suppression of cell growth Homo sapiens